The Favorskii reaction refers to the nucleophilic addition of terminal alkynes to carbonyl compounds in the presence of a basic medium (e.g., anhydrous potassium hydroxide or sodium amide), yielding propargylic alcohols. The reaction is named after Russian chemist Alexei Yevgrafovich Favorskii, who first reported it. The reaction mechanism involves deprotonation...

The Dakin reaction refers to the transformation of ortho- or para-hydroxy aromatic aldehydes or ketones into corresponding phenols under basic conditions using hydrogen peroxide. This reaction was discovered by Henry Drysdale Dakin in 1909, and is named in his honor. It is an efficient method for synthesizing polyhydroxy aromatic compounds....

The Fleming–Tamao oxidation is a reaction that converts silanes into alcohols using peracids or hydrogen peroxide. The reaction is named after Kohei Tamao and Ian Fleming, who independently reported slightly different versions of this transformation in 1983 and 1984, respectively. Reagents: Hydrogen peroxide or peracid, solvent, fluorinated additives Reactants: Silanes...

Acid chlorides can be selectively reduced to their corresponding aldehydes using hydrogen gas in the presence of a partially deactivated palladium catalyst, known as the Rosenmund catalyst. This catalyst is prepared by depositing palladium (Pd) on barium sulfate (BaSO₄) and then poisoning it with additives such as 2,6-dimethylpyridine, quinoline–sulfur compounds,...

The Conia-ene reaction refers to a class of intramolecular cyclization reactions between enols and alkenes or alkynes. In the late 1960s, the laboratory of Jean-Marie Conia began studying small carbocyclic molecules, particularly those formed via ene-type reactions involving carbonyl compounds. Based on this research, a comprehensive paper titled “The Thermal...

The Hosomi–Sakurai reaction, also known simply as the Sakurai reaction, is an allylation reaction in which allyltrimethylsilane reacts with an electrophile under the catalysis of a strong Lewis acid. This reaction was jointly developed by Professors Hideki Sakurai and Akio Hosomi, and it bears their names. It is one of...