Barton Decarboxylation refers to a radical reaction in which a carboxylic acid is first converted into a thiohydroxamate ester (also known as a Barton ester), and then thermally decomposed in the presence of a radical initiator and a suitable hydrogen donor to yield the decarboxylated product. The reaction is named...
03
Jun
The Favorskii reaction refers to the nucleophilic addition of terminal alkynes to carbonyl compounds in the presence of a basic medium (e.g., anhydrous potassium hydroxide or sodium amide), yielding propargylic alcohols. The reaction is named after Russian chemist Alexei Yevgrafovich Favorskii, who first reported it. The reaction mechanism involves deprotonation...
03
Jun
The Dakin reaction refers to the transformation of ortho- or para-hydroxy aromatic aldehydes or ketones into corresponding phenols under basic conditions using hydrogen peroxide. This reaction was discovered by Henry Drysdale Dakin in 1909, and is named in his honor. It is an efficient method for synthesizing polyhydroxy aromatic compounds....
03
Mar
-- J&K Scientific exclusively offers two monomers developed by Prof. Yin. The fossil resources derived 4,4’-biphenyldicarboxylic acid is a significant monomer in polymer industry [1]. However, its production route is lengthy and dirty with low selectivity, and the corresponding polymers are also poorly biodegradable. In view of increasing concerns about...
23
Mar
Generating α,β-unsaturated carboxylic acids (cinnamic acid derivatives) in the presence of a weak base from aromatic aldehydes with the anhydrides of aliphatic carboxylic acids is known as the Perkin reaction. An enolate intermediate is made from the anhydride, which undergoes a condensation reaction with benzaldehyde, followed by an intramolecular acyl...
17
Feb
The Finkelstein reaction uses acetone and a metal halide salt to exchange the halogen atom of an alkyl halide for another halogen atom via an SN2 reaction. The substituted metal halide being less soluble than the original metal halide in acetone (Le Chatelier’s principle) drives the reaction forward. Reagents: Acetone,...
