Adenosine triphosphate (ATP) is the primary energy carrier in cellular activities. In mitochondria, ATP drives essential biochemical and biosynthetic processes, such as oxidative phosphorylation, which can significantly impact mitochondrial function. Abnormal ATP metabolism is linked to several severe diseases, including ischemia, Parkinson’s disease, and malignant tumors. To better understand ATP’s...

NIRII-HDs fluorescent dyes (Figure 1), developed by the Zhang Xiaobing-Yuan Lin research group, are designed for near-infrared II (NIR-II) region imaging. Compared to near-infrared I (NIR-I) and visible light, NIR-II dyes provide deeper tissue penetration and lower spontaneous background fluorescence, making them highly effective for in vivo imaging applications. These...

Two-photon imaging is a powerful technique in biomedical research and clinical diagnostics, offering deeper tissue penetration and reduced photodamage. The most commonly used two-photon dyes are electron donor-acceptor (D–A) type molecules, but their application is often hindered by solvation quenching effects, leading to reduced fluorescence efficiency. To overcome this challenge,...

The TPQL-1 and TPQL-2 fluorescent dyes, developed by the Zhang Xiaobing-Yuan Lin research group at Hunan University, are innovative two-photon dyes designed through a single-atom substitution and electron acceptor combination strategy based on the 6-ethyl-2-dimethylaminonaphthalene (acedan) structure (Figure 1). [1] In recent years, two-photon fluorescent dye imaging has gained widespread...

The Zhang Xiaobing-Yuan Lin research group at Hunan University has developed a novel single-benzene-based fluorescent dye (SBFs) (Figure 1). This dye offers universal emission wavelength tunability, covering the entire visible spectrum in both solutions and solid states [1]. By overcoming the strong intramolecular and intermolecular hydrogen bonding limitations of most...

DQF Fluorescent Dye – A Rhodamine-Based Dye with Large Stokes Shift Organic small-molecule fluorescent dyes have been widely applied in functional molecular labeling and detection, offering real-time, in-situ visualization for various biomedical research applications. However, most commonly used fluorescent dyes—such as fluorescein, rhodamine, oxazine, and cyanine—suffer from small Stokes shifts...