Metal-catalyzed cross-couplings are widely used for the C-C bonds formation in organic synthesis, particularly for unsaturated scaffolds production. However, there were several challenges to develop a general method for the direct deoxygenative cross-coupling of free alcohols, using as native sp3-hybridized functional groups. Challenges: the in situ cleavage of strong C–O...

Novel chiral phosphite ligands with stable properties, mild reaction conditions, high catalytic yields and enantioselectivity. Chirality is closely related to life phenomena and significantly affects material properties. Our demand for optically active substances has led to rapid progress in the research and development of chiral compounds. Dr. Lailai Wang has...

Qinheng Zheng Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA Click chemistry and drug discovery are a perfect match One of the most profound advancements of modern chemistry is click chemistry. Ranked top of the most cited papers in the history of chemistry is...

RNA molecules have various applications in living cells, such as 1) transmission and translation of genetic information, 2) structural support of molecular machines, 3) regulation of gene expression, silencing and catalysis. Obtaining a complete spatiotemporal distribution of RNA synthesis, processing, and transportation is essential for understanding the function and behavior...

Polyadenylic acid (also known as poly(A), poly(A) carrier or carrier RNA) is a synthetic homopolymer composed of a long single-stranded (100-500 kDa) sequence of adenine (A) nucleotides available in lyophilized form. Its charge, shape and ability to residue-stack is modulated by solvent composition. It is structurally identical to poly(A) tails,...

What are Organolithium Compounds? Organolithium compounds (RLi) are organometallic compounds that contain carbon – lithium bonds. Unlike Grignard reagents which inserts between the carbon and halide bond, Lithium replaces the halide to form organolithium, forming a stronger partial negative charge on the carbon. Organolithium reagents act as good “nucleophilic carbons”...