Newman–Kwart Rearrangement (NKR) refers to the thermal rearrangement of O-thiocarbamates to their corresponding S-thiocarbamates under high-temperature conditions. The reaction is named after its discoverers, Melvin Spencer Newman and Harold Kwart. The NKR is an important method for the synthesis of thiophenols and their derivatives. Reagents: Solvent (e.g., DMA, NMP) Reactant:...

The Michaelis–Arbuzov reaction (also known simply as the Arbuzov reaction) refers to the transformation where trivalent phosphite esters react with alkyl halides to produce pentavalent alkyl phosphonates. The reaction was first discovered by August Michaelis in 1898 and later thoroughly investigated by Aleksandr Arbuzov. The Michaelis–Arbuzov reaction is one of...

The Finkelstein Reaction involves the substitution of a halogen atom in an alkyl halide with another halogen atom via an SN2 reaction, using acetone and a metal halide salt. The driving force behind the reaction is the lower solubility of the newly formed metal halide salt in acetone compared to...

Dess–Martin Oxidation refers to the oxidation of alcohols to the corresponding carbonyl compounds using Dess–Martin periodinane (DMP). The reaction is named after American chemists Daniel Benjamin Dess and James Cullen Martin. Dess–Martin periodinane (DMP), full name: 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one, was developed in 1983 by the aforementioned chemists. The Dess–Martin oxidation can proceed...

Barton Decarboxylation refers to a radical reaction in which a carboxylic acid is first converted into a thiohydroxamate ester (also known as a Barton ester), and then thermally decomposed in the presence of a radical initiator and a suitable hydrogen donor to yield the decarboxylated product. The reaction is named...

Fukuyama Coupling refers to the reaction between organozinc compounds and thioesters under palladium catalysis to produce ketones. This reaction was discovered by Tohru Fukuyama and colleagues in 1998 and is named after him. Fukuyama Coupling has attracted widespread attention for its mild reaction conditions and high functional group compatibility, making...