Ligands play a critical role in chemical synthesis, bonding with metal central atoms through coordination or covalent bonds. These interactions directly influence the chemical environment around the metal atoms, improving reaction conditions, catalytic activity, and conversion rates. Over the years, scientists have developed thousands of chiral ligands to meet the growing demands of modern chemistry.

Since 2014, Professor Zhang Junliang’s research group has developed the SadPhos ligand, a new generation of chiral ligands with adaptive coordination. SadPhos features non-C2 symmetry and incorporates a variety of soft and hard coordination atoms. These ligands can function as monophosphine ligands, N,P-ligands, P,S-ligands, and P,O-ligands, exhibiting flexible coordination modes with various transition metals and metal valence states.

Evolution of the SadPhos Family

After nearly a decade of development, the SadPhos family has expanded significantly:

• Timeline of Development:
  • Ming-Phos (2014)
  • Xiao-Phos (2015)
  • Wei-Phos (2015)
  • Peng-Phos (2016)
  • Xiang-Phos (2016)
  • PC-Phos (2017)
  • Xu-Phos (2018)
  • WJ-Phos (2019)
  • Le-Phos (2019)
  • TY-Phos (2020)
  • GF-Phos (2021)
  • W-Phos (2022)
  • Rong-Phos (2023)

These ligands have been featured in more than 100 research papers published in renowned international journals. Among them, the Peng-Phos ligand, introduced in 2016, has demonstrated exceptional enantioselectivity in reactions such as asymmetric Michael addition and asymmetric intermolecular Rauhut–Currier reactions.

J&K Scientific offers a comprehensive range of Peng-Phos ligands, designed to meet the needs of researchers worldwide. These ligands are available in high purity and at competitive prices in large packages.

• Product Identification:
  Structures are verified through hydrogen nuclear magnetic resonance spectroscopy and phosphorus spectroscopy, ensuring accuracy and consistency.

• Comprehensive Range:
  J&K Scientific provides an extensive array of products, including chiral ligands, metal catalysts, organic molecular catalysts, chiral building blocks, chiral prosthetic groups, chiral reagents, and chiral separation reagents.

• Cutting-Edge Innovation:
  Access the latest chiral ligands and catalysts derived from cutting-edge scientific research.

• Quality Assurance:
  Rigorous quality control ensures high purity and stable batch quality for reliable results.

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