G-quadruplex (G4) fluorescent probes provide ideas for broadening viromics research on functional nucleic acids and developing new HCV infection detection. However, the traditional G4 dye has poor ability to cross cell membranes and is difficult to be directly used for live cell imaging.Hunan University's Nie Zhou team developed a new...

More than 170 million people worldwide are infected with hepatitis C virus (HCV), a single-stranded positive-strand RNA virus. Once the human body is infected, it is very likely to develop diseases such as chronic hepatitis, cirrhosis and even liver cancer. Currently, the commonly used methods for detecting HCV infection in...

Metal-organic frameworks (MOFs) are a type of coordination polymer that has developed rapidly in recent years. Due to its excellent characteristics such as structural diversity, porosity, tailorability and high specific surface area, it has been widely used in gas adsorption and storage, molecular separation, Many fields such as catalysis, drug...

The basic building blocks of biomimetic homopolypeptides are protected or unprotected glutamic acid or lysine residues, which are obtained through ring-opening polymerization of cyclic amino acid anhydrides. They can be used in the field of biomedicine as drug delivery, gene delivery carriers or degradable biomimetic medical materials [1-2]. They can...

Click Chemistry is a synthesis concept proposed by Sharpless, a Nobel Prize winner in chemistry from the United States, in 2001 [1]. Among them, the main and classic click chemical reaction is the Cu(I)-catalyzed azide-alkynyl Husigen cycloaddition reaction (CuAAC). This reaction has the advantages of high yield, few side reactions,...

Polyethylene glycol functional chain compounds can modify the surface of proteins or substances and are used in the study of covalent macromolecule proteins, serving as connecting arms while enhancing the functional properties of proteins. For example: Adding polyethylene glycol to the protein modification improves the water solubility of the protein,...