The Zhang Xiaobing-Yuan Lin research group has developed an extensive range of groundbreaking fluorescent dyes, each optimized for specific scientific and biomedical applications. These advanced dyes offer high brightness, excellent photostability, and a wide range of functionalities, catering to modern imaging and labeling needs.

1. High Brightness and Photostability Protein Labeling Dyes — YueLu (YL) Dyes

• Key Features:

  • High brightness: $66,400 \, M^{-1} \, cm^{-1}$ compared to $32,500 \, M^{-1} \, cm^{-1}$ of traditional dyes.
  • Larger Stokes shift: 52 nm vs. 27 nm for conventional dyes.
  • Superior photostability: Enables capturing up to five times more frames before brightness reduces by half.

• Applications:
  Probes constructed with YueLu dyes are ideal for protein labeling and long-term super-resolution imaging.

2. Near-Infrared Fluorescent Dyes — Huda (HD) and Changsha (CS) Dyes

• Key Features:

  • Multiple modification sites for constructing activated fluorescent probes.
  • Compatibility with targeting groups for designing probes aimed at specific organs or sites.

• Applications:

  • In vivo detection of active biomolecules.
  • Detection of organ damage caused by diseases, providing excellent imaging results.

3. Rh6G-ACFPN Fluorescent Probe for ATP Monitoring

• Key Features:

  • High selectivity and sensitivity.
  • Appropriate dissociation constant: $4.65 \, mM$, ideal for monitoring mitochondrial ATP levels ($3-10 \, mM$).
  • Reversible response for dynamic monitoring.

• Applications:
  Real-time monitoring and quantification of ATP in living cells.