Innovative Deuterated Methylated Aromatics by Professor Zhou Qianghui: Transforming Medicinal Chemistry Methyl groups are commonly found in small-molecule drugs and play a vital role in enhancing drug properties. Numerous studies demonstrate that introducing methyl groups at specific sites in candidate drugs can: Improve metabolic stability, Shorten half-life, Enhance solubility and...

Superfan compounds are a novel class of molecular cages with unique structural features. Composed of two parallel benzene rings connected by six side chains, these compounds form a lantern-like structure with a (quasi-) closed internal cavity and numerous recognition sites distributed around the cavity. Compared to traditional supramolecular host compounds,...

Polyethylene glycol (PEG) functional chain compounds play a pivotal role in modifying the surface of proteins and materials. These compounds facilitate covalent macromolecular protein research by acting as linking arms while enhancing the functional properties of proteins. Applications of PEG Functional Chain Compounds Protein Surface Modification: Improves protein water solubility....

Photodynamic therapy (PDT) is a method that combines photosensitive drugs and laser activation to treat cancer. It has the advantages of minimally invasiveness, strong spatiotemporal controllability, small side effects, and low incidence of drug resistance. Traditional PDT uses light to excite a photosensitizer (PS) and transfer energy to oxygen to...

      Small molecule cyanine is a type of strong absorbing ligand with red or near-red light, which can red-shift the absorption intensity of molecules. It has important applications in the fields of synthetic ligands for metal complexes and intermediates for the synthesis of molecular probes. In addition, cyanine...

Triptycene and its derivatives are a class of compounds with a unique three-dimensional rigid structure and are widely used in many fields such as molecular machines, materials chemistry, and supramolecular chemistry [1]. Researcher Chen Chuanfeng from the Institute of Chemistry, Chinese Academy of Sciences, successfully synthesized a new host molecule...