Biological Activity Tamoxifen is a selective estrogen receptor modulator (SERM) that evokes tissue-dependent effects. As an antagonist of estrogen receptor (ER) activity in breast tissue and breast cancer cells, it is commonly used in the prevention and treatment of (ER)-positive breast cancer patients. In cells, it is converted to active...

Biological Activity Valproic acid, derived from naturally occurring valeric acid is an FDA approved drug that has long been used in the treatment of epilepsy and other neuropsychiatric disorders, associated with its action on γ amino butyric acid (GABA) levels in the brain and voltage-gated ion channels. [1] It is...

Biological Activity Resveratrol is a phenolic phytoalexin found in grape skin and at least 72 other plant species that is involved in a diverse range of biological activities (and targets) with anti-inflammatory, cardiovascular protective, cancer chemopreventive, among other beneficial properties. [1,2] It was also found to increase CRISPR-mediated HDR efficiency,...

Brefeldin A (BFA) Biological Activity Brefeldin A (BFA) is a fungal lactone metabolite that (reversibly) inhibits intracellular protein transport from the endoplasmic reticulum (ER) to the Golgi apparatus. [1] It also activates the sphinogomyelin cycle, [2] and exhibits considerable in vitro and in vivo antitumor activity, associated with autophagy and...

L-755507 | CAS:159182-43-1 Biological Activity L-755507 is a potent partial agonist of β3-adrenergic receptor with an EC50 value of 0.43 nM for cloned human receptors, [1] with over 400-fold selectivity for the β3-receptor over β1- and β2- receptors. L-755507 was found to stimulate lipolysis in human adipose tissue [2] and promote...

Thymidine: Increase HDR via cell cycle synchronization CAS #: 50-89-5 Biological Activity Composed of the pyrimidine base thymine attached to the sugar deoxyribose, thymidine is converted to the corresponding nucleotide prior to in vivo DNA synthesis. In the DNA double helix, thymine base pairs with adenine. As a cell synchronization...