Small molecule cyanine is a type of strong absorbing ligand with red or near-red light, which can red-shift the absorption intensity of molecules. It has important applications in the fields of synthetic ligands for metal complexes and intermediates for the synthesis of molecular probes. In addition, cyanine ligands can generate reactive oxygen species under light conditions and have potential applications in the field of photodynamic therapy of tumors.

      Professor Zhang Pingyu of Shenzhen University developed a class of small molecule cyanine ligands and designed a new type of platinum (II) complex (Pt-Cy) containing a cyanine skeleton. Research results show that Pt-Cy can produce reactive oxygen species (ROS) under both ultrasound (US) and light irradiation; compared with dark conditions, Pt-Cy exhibits US and photocytotoxicity under light irradiation; its in vivo sonodynamic therapy ( SDT) is more efficient than photodynamic therapy (PDT) [1]. Pt-Cy extends the biological applications of metal complexes from PDT to SDT.

Figure 1 Pt-Cy structure

Zhang Pingyu, Distinguished Professor of Shenzhen University, Youth Yangtze River Scholar of the Ministry of Education, Royal Newton Scholar, and doctoral supervisor. He has long been focusing on the basic research of metal complexes in the field of tumor treatment, and has carried out systematic research on the photodynamic therapy, sonodynamic therapy and mechanisms of metal complexes, providing new structures and new strategies for the development of efficient metal drugs. At the same time, metal drugs are used as tools to reveal the occurrence and development of tumor diseases, and chemical biology methods and technologies are combined to elucidate the mechanism of metal drugs intervening in cancer stem cell pathways, providing a theoretical basis for clinical research on metal drugs.

Bailingwei exclusively supplies three kinds of small molecule cyanine ligands developed by Professor Zhang Pingyu of Shenzhen University, which can be used as ligands for coordination metal centers, which can red-shift the absorption intensity and molar absorption coefficient of molecules and improve photosensitization efficiency.

Product list

Product name:
Cyanine derivative 1, 99%
Item number：9333886

Product name:
Cyanine derivative 2, 99%
Item number：9333887

Product name:
Cyanine derivative 3, 99%
Item number：9333888

References

1. Lai Y, Lu N, Ouyang A, et al. Ferroptosis promotes sonodynamic therapy: a platinum (II)–indocyanine sonosensitizer[J]. Chemical Science, 2022, 13(34): 9921-9926.