Ynamides (MYMsA and MYTsA) are stable，easy to handle, and able to avoid racemization during the activation of carboxylic acid and formation of amide bond. Ynamides (MYTsA and MYMsA, Fig. 1) are a type of reagents, developed by Dr. Junfeng Zhao, for direct condensation of acids followed by amines.   Advantages...

One-step Multi-functionalization of Aromatic Alkynes Aromatic alkyne allows efficient ortho di-functionalization of the aromatic ring. For example, the aryne precursor Kobayashi can functionalize two groups at the 1,2-position of the benzene ring. Would it be possible to achieve tri-functionalization of aromatic rings by aromatic alkynes? Dr. Yang Li has developed...

A Fluorogenic Probe for Ultrafast and Reversible Detection of Formaldehyde in Neurovascular Tissues PFM (Fig. 1) is a fluorogenic probe suitable for the detection of formaldehyde in living cells with excellent temporal and spatial resolution.  Fluorescent probes based on regular fluorophores usually suffer from a low cell permeability and an...

Novel chiral phosphite ligands with stable properties, mild reaction conditions, high catalytic yields and enantioselectivity. Chirality is closely related to life phenomena and significantly affects material properties. Our demand for optically active substances has led to rapid progress in the research and development of chiral compounds. Dr. Lailai Wang has...

Homogeneous HA/HC Polysaccharides Hyaluronan (HA) and chondroitin (CH) are two important Glycosaminoglycans that widely exist on the cell surface and in the extracellular matrix. They are able to interact with cytokines, cell adhesion molecules, selectins and enzymes to regulate intracellular signaling pathways [1]. Also, they have various applications in pharmaceuticals...

The Mitsunobu reaction uses triphenylphosphine (PPh3) and diethyl azodicarboxylate (DEAD) to convert a 1° or 2° alcohol into a wide variety of final products, dependent on the mildly acidic nucleophile (H-Nuc) used. H-Nuc transfers its proton to the zwitterionic adduct formed from PPh3 attacking the DEAD. The resulting phosphonium intermediate...