Innovative Deuterated Methylated Aromatics by Professor Zhou Qianghui: Transforming Medicinal Chemistry

Methyl groups are commonly found in small-molecule drugs and play a vital role in enhancing drug properties. Numerous studies demonstrate that introducing methyl groups at specific sites in candidate drugs can:

• Improve metabolic stability,
• Shorten half-life,
• Enhance solubility and target selectivity, and
• Alter drug effects, such as converting an agonist into an antagonist.

When the hydrogen atom in the methyl group is replaced with a deuterium atom, the resulting compound can clarify drug mechanisms, slow drug metabolism, and increase activity. It also improves the stability of enantiomers, inhibits configuration conversion, and reduces drug toxicity.

 

Dual-Tasked C-H Methylation: A Groundbreaking Strategy

Traditional methylation methods are limited to single methylation, and introducing deuterated methyl groups requires expensive reagents. To address these challenges, Professor Zhou Qianghui of Wuhan University developed an innovative Dual-Tasked C-H Methylation strategy based on the Catellani reaction [1][1]

 

About Professor Zhou Qianghui

Professor Zhou Qianghui is a distinguished chemist with extensive expertise in organic synthesis and medicinal chemistry. His academic milestones include:

Education: Bachelor’s degree from Peking University (2005) and a Ph.D. from the Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (2010).
Research: Postdoctoral work at Scripps Research Institute under Professor Phil S. Baran (2011–2015).
Current Role: Professor at Wuhan University, focusing on bioactive molecule synthesis, green drug process development, and innovative synthesis methodologies.

His achievements include the WuXi AppTec Life Chemistry Research Award (2022) and selection into the National High-Level Talent Youth Project (2015). Professor Zhou also serves as Deputy Secretary-General of the Process Chemistry Committee of the Chinese Chemical Society and as a young editorial board member of multiple prestigious journals.

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J&K Scientific: Exclusive Supplier of Deuterated Methylated Aromatics

J&K Scientific is proud to exclusively supply a series of high-purity, structurally diverse deuterated methylated aromatics developed by Professor Zhou Qianghui. These compounds are essential for advancing research in medicinal chemistry and related fields.

 

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