Polyethylene glycol (PEG) functional chain compounds play a pivotal role in modifying the surface of proteins and materials. These compounds facilitate covalent macromolecular protein research by acting as linking arms while enhancing the functional properties of proteins.
Applications of PEG Functional Chain Compounds
Protein Surface Modification:
- Improves protein water solubility.
- Reduces the immunogenicity of labeled molecules.
- Enhances stability in vivo.
- PEG spacers functionalize surfaces such as quantum dots, self-assembled monolayers, and nanoparticles.
- Significantly reduces non-specific protein binding, enabling more precise applications.
Researcher Li Xuebing from the Institute of Microbiology, Chinese Academy of Sciences, has developed a series of cutting-edge polyethylene glycol functional chain products.
One notable example is propynyl-triethylene glycol-amino (Product No.: 9110656). This compound, illustrated in Figure 1, connects two single-chain antibody fragments (scFv), effectively preventing them from forming dimers or trimers. By reducing undesired yields, it enables the synthesis of bivalent scFv (di-scFv) with an impressive yield of up to 74%【1】
J&K Scientific proudly supplies polyethylene glycol functional chain compounds, facilitating advancements in protein modification and surface functionalization research.
Figure 1 BTTAA (Cat. No.: 9058700) is used for biomolecule labeling [2]
CuAAC reaction catalyst ligand
BTTAA
50mg
100mg
Vicky Zhao
