To address the challenge that most chiral metabolites lack chromophores and are difficult to detect with high sensitivity, Professor Min Junzhe’s team at Yanbian University has developed a novel fluorescent chiral derivatization reagent—DBD-M-Pro. This reagent integrates both a fluorescent group and a chiral center, enabling precise labeling of amino-containing chiral...

Drug overdose can lead to drug-induced liver injury (DILI), thereby exacerbating liver failure. Extensive research has shown that a rapid increase in peroxynitrite (ONOO⁻) levels is considered a key biomarker of early-stage liver injury. Therefore, real-time monitoring of peroxynitrite dynamics can provide deep insights into its specific roles in processes...

🔬 Background & Molecular Design Aggregation-induced emission (AIE) is a photophysical phenomenon in which certain fluorogens emit weak or no fluorescence in solution but exhibit significantly enhanced fluorescence in the aggregated or solid state. In recent years, AIE molecules have gained increasing attention in biomedical imaging. TriPEX is a class...

Benthio Green—A DNA Fluorescent Dye with Large Stokes Shift and Low Toxicity A large Stokes shift (Δλ > 120 nm) reduces spectral crosstalk between excitation and emission, improving the signal-to-background ratio and facilitating high-resolution fluorescence imaging, which is particularly important for high-performance fluorescent dyes.The research team led by Professor Zhou...

Technical Upgrade To overcome the limitations of traditional cell membrane dyes in imaging persistence, Professor Qian Zhaosheng’s research team recently developed the FM 2.0 fluorescent dye series. This new generation of dyes achieves comprehensive upgrades based on FM 1.0 technology! Not only does it extend imaging time to over 2-6...

Aggregation-induced emission (AIE) materials are currently the only new class of materials pioneered by Chinese scientists, originating from the work of Academician Benzhong Tang. Recognized by the International Union of Pure and Applied Chemistry as one of the "Top Ten Emerging Technologies in Chemistry Worldwide," AIE demonstrates unique optical properties...