Aggregation-induced emission (AIE) materials are currently the only new class of materials pioneered by Chinese scientists, originating from the work of Academician Benzhong Tang. Recognized by the International Union of Pure and Applied Chemistry as one of the "Top Ten Emerging Technologies in Chemistry Worldwide," AIE demonstrates unique optical properties and broad application potential. It shows tremendous promise in fields such as precision medicine, enhanced plant photosynthesis, and data storage, positioning it as a foundational technology for future scientific advancement.
Unlike traditional organic luminescent materials, which often suffer from aggregation-caused quenching in solid-state applications, AIE materials exhibit enhanced emission upon aggregation—hence the name "Aggregation-Induced Emission." This distinctive characteristic offers novel solutions for applications such as biological labeling and disease diagnosis and treatment.
In the field of life sciences, AIE materials enable the visualization of viruses, bacteria, and cells by making them emit light. This capability allows researchers to observe otherwise elusive phenomena within biological systems, thereby deepening our understanding of biological structures and life processes.
AIE Organelle-Targeting Fluorescent Probes
AIE Organelle-Targeting Fluorescent Probes are a class of probes based on the Aggregation-Induced Emission (AIE) effect, which remain weakly fluorescent in solution and cellular environments. However, once they enter cells and bind to target structures, their fluorescence signals are significantly enhanced.
AIE Organelle-Targeting Fluorescent Probes — Pioneering a New Era in Cellular Imaging
Compared to traditional ACQ probes, AIE organelle fluorescent probes offer distinct imaging advantages:
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Large Stokes Shift, ensuring high imaging accuracy;
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No-Wash Procedure, simplifying experimental operations;
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High Stability: Excellent photostability allows stable fluorescence signal output during long-term cellular imaging, making them suitable for extended and repeated fluorescence imaging sessions.
AIE Fluorescent Nanoparticles
AIE Fluorescent Nanoparticles are formed by coating AIE molecules with amphiphilic polymers such as polyethylene glycol. The AIE molecules are embedded inside the nanoparticles (Figure 1). Due to the Aggregation-Induced Emission characteristic, no fluorescence quenching occurs upon aggregation, significantly enhancing the fluorescence efficiency of the AIE molecules.
Advantages:
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Excellent Monodispersity: Uniform particle size with CV < 10%.
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High Photostability: Persistent and stable fluorescence signals during multiple in vivo imaging sessions.
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Strong Anti-photobleaching Performance: As AIE-based products, higher concentrations result in stronger fluorescence, making them suitable for high-concentration imaging scenarios (e.g., ureter and intestinal obstruction imaging).
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Good Biocompatibility: Low cytotoxicity to cells and tissues, with a short pharmacokinetic profile.
Related Products：
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