Drug overdose can lead to drug-induced liver injury (DILI), thereby exacerbating liver failure. Extensive research has shown that a rapid increase in peroxynitrite (ONOO⁻) levels is considered a key biomarker of early-stage liver injury. Therefore, real-time monitoring of peroxynitrite dynamics can provide deep insights into its specific roles in processes such as apoptosis, proliferation, and cell migration.
Near-infrared (NIR) fluorescent probes have become powerful tools for studying cellular signaling and molecular mechanisms due to their high sensitivity and specificity. Professor Tang Zhixin from Shandong University of Traditional Chinese Medicine has developed a novel NIR fluorescent probe for peroxynitrite—Peroxynitrite Fluorescent Probe I: DILI-ONOO (Fig. 1). This probe enables the detection and imaging of peroxynitrite mediated by ferroptosis in drug-induced liver injury, offering high selectivity and sensitivity. It facilitates early identification and real-time imaging of liver injury, holding significant potential for the early diagnosis and treatment of ferroptosis-mediated drug-induced liver injury.
Product Advantages
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High Sensitivity: Detection limit as low as 20 μM (Fig. 2);
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Strong Specificity: Minimal interference from other substances (Fig. 3);
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High Purity: ≥90% purity.
| Tang Zhixin is a Lecturer and Master's Supervisor at Shandong University of Traditional Chinese Medicine, holding a Ph.D. from Dalian University of Technology (2020). His research focuses on developing fluorescent probes for disease biomarkers and their applications in bioimaging, as well as utilizing fluorescence-based methods for screening active components in traditional Chinese medicine. He has led research projects funded by the Shandong Natural Science Foundation and the China Postdoctoral Science Foundation. His achievements include receiving the 2024 Science and Technology Award from the China National Association of Ethnic Medicine and a Silver Prize in the National Postdoctoral Innovation Competition. He has published 13 papers as first or corresponding author in journals such as Biosensors and Bioelectronics, Sensors and Actuators B: Chemical, and Analytical Chemistry. | 
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Related Product:
- #Cat:9423824 DILI-ONOO, 90%
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