Global HCV Burden and Detection Challenges Over 170 million people worldwide are infected with the Hepatitis C Virus (HCV), a single-stranded positive-sense RNA virus. Chronic infection often leads to severe liver diseases, including chronic hepatitis, cirrhosis, and liver cancer. Currently, the most common HCV detection methods—fluorescence quantitative PCR and ELISA—are...

Colloidal gold (also known as gold nanoparticles) refers to a dispersion of gold nanoparticles (diameter 1–100 nm) in a solvent, typically water. Due to its excellent stability, biocompatibility, and unique optical and electromagnetic properties, colloidal gold has become a key material in fields such as in vitro diagnostics, biosensing, cancer...

In 2016, Professor Xuechuan Hong at Wuhan University published a paper in Nature Materials [1], reporting the first successful synthesis of a metabolizable near-infrared II (NIR-II) small-molecule dye—CH1055—capable of labeling various biomolecules. With a maximum emission wavelength in the range of 1000–1600 nm, CH1055 exhibits excellent biocompatibility, clearance properties, and imaging sensitivity....

The Importance of Methyl Groups and Deuteration in Drug Development Methyl groups are widely present in small-molecule drugs and play a crucial role. Numerous studies have shown that introducing a methyl group at specific sites in drug candidates can improve metabolic stability, extend half-life, and may also enhance solubility, target...

Due to the difficulty in synthesizing glycan standards, as well as their high cost and limited availability, current quantitative glycan analysis by LC-MS and MALDI-MS primarily relies on relative quantification using isotope labeling. Stable isotope labeling is a technique that uses non-radioactive isotopes to label biomolecules. It enables the labeling...

Background Ferroptosis is a form of programmed cell death characterized by severe dysregulation in the production and degradation of lipid reactive oxygen species (ROS). Peroxynitrite (ONOO−) is one of the most significant reactive oxygen species and a key pathogenic factor in cellular damage. Therefore, monitoring ONOO− levels is of great...