Trifluoromethyldiazomethane (CF₃CHN₂), difluoromethyldiazomethane (CHF₂CHN₂), and formyldiazomethane (CHOCHN₂) are widely used as highly reactive reagents for trifluoromethylation, difluoromethylation, and formylation in the synthesis of organic fluorine compounds and aldehydes. However, these gases are toxic, volatile, and explosive, posing significant safety risks during production, storage, and use. Managing these safety concerns has...

Formyldiazomethane (CHOCHN₂) and difluoromethyldiazomethane (CHF₂CHN₂) are highly reactive, low-molecular-weight compounds widely used to introduce difluoromethyl or aldehyde groups into organic molecules. Despite their value, these functionalized diazomethane derivatives pose significant safety risks due to their gaseous state, volatility, toxicity, and explosiveness under standard conditions. Existing production methods require handling explosive...

Trifluoromethyldiazomethane (CF₃CHN₂) is a crucial precursor for introducing trifluoromethyl groups into organic molecules, widely applied in organic synthesis. Despite its importance, traditional production methods present significant challenges in storage, safety, and handling risks (see Figure 1). To solve these issues, Professor Bi Xihe’s research group at the School of Chemistry,...

In organic synthesis, sulfur dioxide (SO₂) is a crucial reagent, but commonly used SO₂-releasing compounds come with significant limitations: Sodium sulfite (Na₂SO₃): Requires concentrated sulfuric acid, generating excessive heat. Sodium metabisulfite (Na₂S₂O₅) & potassium metabisulfite (K₂S₂O₅): Often demand high temperatures and phase transfer catalysts. Sodium hydroxymethylsulfonate (HOCH₂SO₂Na·2H₂O): Highly hygroscopic, leading...

γ-Ketosulfones are crucial building blocks in medicinal chemistry, serving as key bioactive components in antibacterial, anticoagulant, and antitumor drugs. However, traditional synthesis methods typically involve: Oxidation of γ-ketothioethers: Requires strong oxidants and harsh conditions. Derivatization of sulfinates: Involves cumbersome, multi-step processes. These limitations hinder broader applications, making it difficult to...

Sulfones are widely found in biomolecules and pharmaceuticals, serving as essential building blocks in synthetic chemistry. Similarly, the trifluoromethylthio (-SCF₃) group plays a crucial role in drug design and synthesis due to its strong electron-withdrawing properties. Professor Lian Zhong from Sichuan University has developed a Cu-catalyzed multicomponent reaction that enables...