Polyadenylic acid (also known as poly(A), poly(A) carrier or carrier RNA) is a synthetic homopolymer composed of a long single-stranded (100-500 kDa) sequence of adenine (A) nucleotides available in lyophilized form. Its charge, shape and ability to residue-stack is modulated by solvent composition. It is structurally identical to poly(A) tails,...

What are Organolithium Compounds? Organolithium compounds (RLi) are organometallic compounds that contain carbon – lithium bonds. Unlike Grignard reagents which inserts between the carbon and halide bond, Lithium replaces the halide to form organolithium, forming a stronger partial negative charge on the carbon. Organolithium reagents act as good “nucleophilic carbons”...

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The Finkelstein reaction uses acetone and a metal halide salt to exchange the halogen atom of an alkyl halide for another halogen atom via an SN2 reaction. The substituted metal halide being less soluble than the original metal halide in acetone (Le Chatelier’s principle) drives the reaction forward. Reagents: Acetone,...

  The separation of ionic and ionizable analytes can be effectively achieved using a reversed-phase high performance liquid chromatographic (RP-HPLC) technique called ion-pair chromatography (IPC).  Used on reversed phase columns which are more efficient than columns used in ion exchange chromatography, resulting in better resolution  Sharper peak shapes and highly reproducible...

Ion-pair reagents (IPR) are used in reversed-phase liquid chromatography (RP-LC) and has effectively separated ionic or ionizable analytes.  Successful applications of Ion-pair Reagents Single- and double- stranded RNA / biological or synthetic (2011) [1] Stationary Phase: Non-porous polymeric columns and monolithic polymeric capillary columns Ion-Pair Reagent: Various traditional or volatile amine cation salts Detector: Fluorescent-based...