Homogeneous HA/HC Polysaccharides

Hyaluronan (HA) and chondroitin (CH) are two important Glycosaminoglycans that widely exist on the cell surface and in the extracellular matrix. They are able to interact with cytokines, cell adhesion molecules, selectins and enzymes to regulate intracellular signaling pathways [1]. Also, they have various applications in pharmaceuticals and cosmetics.

Current commercially available HA/CH is either isolated from rooster combs or produced by microbial fermentation.[2][2]



  • Higher identification ability of conventional immobilized metal affinity chromatography: 3 times of Fe3+-IMAC, 1.3 times of TiO2
  • Enrichment specificity up to 95%[3]
  • Better selectivity and enrichment efficiency than Zr-IMAC, ZrO2, etc. [4][5]



  1. Fu, Xuan, Wenjing Shang, Shuaishuai Wang, Yunpeng Liu, Jingyao Qu, Xi Chen, Peng George Wang, and Junqiang Fang. "A general strategy for the synthesis of homogeneous hyaluronan conjugates and their biological applications." Chemical Communications 53, no.
  2. Chong, Barrie Fong, Lars M. Blank, Richard Mclaughlin, and Lars K. Nielsen. "Microbial hyaluronic acid production." Applied microbiology and biotechnology 66, no. 4 (2005): 341-351.

Homogeneous Hyaluronan polymers, 90%
9185393 (n=100)
950363 (n=500)
958159 (n=1000)

Homogeneous chondroitin polymers, 90%
9185394 (n=100)
939226 (n=500)
922063 (n=1000)

Dr. Ye’s Profile

He is an associate professor from National Glycoengineering Research Center of Shandong University. His research interests are: 1. Modular enzymatic synthesis strategy of homogeneous glycosaminoglycans 2. Synthesis of complex oligosaccharides by enzymatic method and its applications 3. Sugar nucleotides’ synthesis pathway and scale up methods.







2749380 CAE-Ti-IMAC, 100%

By shuhan yang


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