AZT as HDR Inhibitors Biological Activity Approved by the FDA in 1987,[1] and still used in combination treatment, azidothymidine (AZT) is a thymidine (nucleoside) analogue that is phosphorylated in the host (by enzymes of the thymidine-phosphorylation pathway) to AZT-triphosphate, which inhibits viral (HIV-1) reverse transcriptase activity about 100-fold better than...
12
May
Aphidicolin: Increase HDR via Cell Cycle Synchronization Biological Activity Isolated from the fungus C. aphidicola, aphidicolin is a potent (cell permeable) inhibitor of the B-family of DNA polymerases, (reversibly) arresting replication in eukaryotes, bacteria, and certain animal viruses (SV40, Herpes, Vaccinia) at the G1-S border. Used as a cell synchronization...
12
May
The One-stop Guide to Working with Compressed Gases and Chemicals under Pressure: from Hazard Classification and Leaky Cylinders to Mitigating Risks What are gases and chemicals under pressure? Gases under pressure are those that are contained in a receptable at a pressure of 200 kPa (gauge) or more at 20°C....
30
Apr
The Comprehensive Guide to Selecting the Best Lab Coat for Your Application Protection and an iconic badge of honour This form of personal protective equipment (PPE) is worn (like a badge of honor) over street clothing to keep us safe from hazardous materials such as chemicals, biological substances, and radioactive...
02
Apr
Qinheng Zheng Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA Click chemistry and drug discovery are a perfect match One of the most profound advancements of modern chemistry is click chemistry. Ranked top of the most cited papers in the history of chemistry is...
26
Mar
A Fluorescent Multifunction Hantzsch Ester (4-(3-((2-(Methacryloyloxy)ethoxy)carbonyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin-4-yl)phenyl)boronic acid, 99% CAS: 2242502-13-0Cat. No.: 9172863 Dr. Tao has developed a multifunctional Hantzsch ester (9172863) with promising applications. Hantzsch ester 9172863 can be polymerized by reacting with poly(ethylene glycol methyl ether) methacrylate (PEGMA). This fluorescent polymer could be used for biomedical research to tag, for...
