2/3 of human proteins can be phosphorylated. The signal network of phosphorylation sites provides information to determine physiological status of cells, identify disease markers, and discover drug targets. Achieving higher specific enrichment of phosphoproteins or phosphopeptides would reduce sample complexity, suitable for applications such as MS-based phosphoproteome analysis. For this...

Second region near-infrared (NIR-II) fluorescence imaging has been used widely in vivo due to its long excitation wavelength and the ability to achieve deep penetration depths, and high spatial resolution. However, existing NIR-II fluorescent probes, such as single-walled carbon nanotubes (SWNTs), quantum dots, rare-earth nanoparticles, and other inorganic materials or...

Generating α,β-unsaturated carboxylic acids (cinnamic acid derivatives) in the presence of a weak base from aromatic aldehydes with the anhydrides of aliphatic carboxylic acids is known as the Perkin reaction. An enolate intermediate is made from the anhydride, which undergoes a condensation reaction with benzaldehyde, followed by an intramolecular acyl...

RNA molecules have various applications in living cells, such as 1) transmission and translation of genetic information, 2) structural support of molecular machines, 3) regulation of gene expression, silencing and catalysis. Obtaining a complete spatiotemporal distribution of RNA synthesis, processing, and transportation is essential for understanding the function and behavior...

Repurposed from a prokaryotic adaptive immune response, the CRISPR/Cas9 system has become a powerful RNA-guided genome-editing tool for targeting and manipulating virtually any genomic sequence, since its inception in 2012.  Nowadays CRISPR is being used in a plethora of applications including the elucidation of gene function involved in disease, the...

Probe Na-8, 90%Cat. No.: 2698428Appearance: Off-white powder Why is it important to track GSH fluctuation? Chemotherapy is currently the main treatment for cancer, but tumor cells may develop resistance to chemotherapy regimens. Drug resistance is mediated by multiple factors, among which, high levels of glutathione (GSH) is surmised to be a...