Coined by K. Barry Sharpless, Hartmuth C. Kolb, and M.G. Finn in 2001, click chemistry is a term used to describe reactions that rapidly and selectively react or “click” with each other in a predictable way to form physiologically stable products with heteroatom links (C-X-C). Widely used in the modification of biomolecules, surfaces,...

Want to avoid violation fines and enhance lab safety when dealing with hazardous waste? The first step to avoiding any penalties is determining if the waste produced in your laboratory is hazardous according to the jurisdiction that you are in. In the United States for instance, failure to comply with...

Metal-catalyzed cross-couplings are widely used for the C-C bonds formation in organic synthesis, particularly for unsaturated scaffolds production. However, there were several challenges to develop a general method for the direct deoxygenative cross-coupling of free alcohols, using as native sp3-hybridized functional groups. Challenges: the in situ cleavage of strong C–O...

The one-stop guide to working with flammable material: from hazard classification to mitigating risks What are flammables? Flammable materials are those gases, liquids, and solids that upon exposure with an ignition source (e.g. open flames, sparks, heat-producing chemical reactions, etc.) will ignite and continue to burn in air.  Many flammable...

The ultimate guide to working with explosives: from hazard classification to primary & secondary effects What are explosives?  Explosives are solid or liquid substances (or mixtures) with an intrinsic ability to undergo rapid chemical reactions that produce high temperature and pressure gases which travel at high enough speeds to cause...

The ultimate guide for 9 types of chemical spills and cleanup procedures Plan for spills “Failing to plan is planning to fail”: prepare to act in a safe, timely, and effective manner during chemical spills (or releases) by walking through minor/major spill protocols, optimizing lab space and organization, and reviewing...