A major challenge in the development of a chromatographic method is the rational selection of experimental conditions that can provide adequate resolution in a reasonable run time. To increase the retention of ionic and polar analytes with a reversed phase column, it is important to choose an oppositely charged ion-pair...

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     Biological Activity For double-stranded DNA (ds-DNA) repair templates, RS-1 stimulates the binding of human HDR protein RAD51 (hRAD51) to cleavage-induced single-stranded DNA (ss-DNA) over-hangs, which enhances HDR proficiency by facilitating the formation of active presynaptic filaments and stabilizing ss-DNA-RAD51 nucleoprotein filaments, without inhibiting hRAD51 ATPase activity. [ 1 ]...