Polysulfamide is a linear polymer with selective metal (palladium) adsorption capacity. The research group of Professor Yi Wenbin of Nanjing University of Science and Technology has developed a general method for preparing polysulfamide using secondary amines, and uses palladium to assist the synthesis of polysulfamide. A palladium-crosslinked polysulfamide skeleton metal...

Azasaccharides are a class of sugar mimetics with important biological and pharmacological activities and play an important role in glycochemistry and glycobiology [1]. Studies have shown that azasugar exhibits excellent glycosidase inhibitory activity, glycosyltransferase inhibitory activity and nucleoside phosphorylase inhibitory activity. Therefore, azasugar has broad application prospects in the treatment...

In August 2018, the team of Academician Shao Feng, deputy director of the Beijing Institute of Life Sciences, published a research paper titled "Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose" in Nature, proving for the first time that two Adenosine heptose monophosphate (ADP-heptose) can be used...

Benzo[a]pyrene (B[a]p) is a typical polycyclic aromatic hydrocarbon with strong teratogenic, carcinogenic and mutagenic properties. After entering the human body, it undergoes a series of metabolic activation to generate 7,8-diol-9, 10 Epoxy benzopyrene (benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide, BPDE). This metabolite has two pairs of enantiomers: (±)anti-BPDE and (±)syn-BPDE. A large number of studies...

The Ullman reaction was discovered by Ullman in 1903. It usually refers to a copper-catalyzed cross-coupling reaction between an aryl halide and a nucleophile such as oxygen, nitrogen, sulfur, phosphorus or carbon. This reaction not only requires the use of an excess of copper catalyst, but also requires high temperature...

Studying the spatial distribution of proteomes in cells is of great significance for elucidating many molecular mechanisms in cell biology. In recent years, proximity chemical labeling technology represented by APEX (The engineered ascorbate peroxidase) has developed rapidly, achieving proximity labeling of proteins and RNA in specific spatial regions within a...