Ligands, which bond with metal central atoms through coordination or covalent bonds, play a critical role in influencing the chemical environment of metal atoms. They improve reaction conditions, enhance catalytic activity, and boost conversion rates. Over the years, scientists have developed thousands of chiral ligands to meet the demands of modern chemistry.

Since 2014, Professor Zhang Junliang’s research group has been pioneering the development of SadPhos ligands. These chiral ligands feature adaptive coordination, non-C2 symmetry, and a variety of soft and hard coordination atoms, such as N, P, S, and O. They can function as monophosphine ligands, N,P-ligands, P,S-ligands, and P,O-ligands, adopting flexible coordination modes with various transition metals across different valence states.

The Evolution of the SadPhos Family

Over the past nine years, the SadPhos family has undergone remarkable growth, beginning with Ming-Phos in 2014 and expanding to include several innovative ligands:

• Ming-Phos (2014)
• Xiao-Phos (2015)
• Wei-Phos (2015)
• Peng-Phos (2016)
• Xiang-Phos (2016)
• PC-Phos (2017)
• Xu-Phos (2018)
• WJ-Phos (2019)
• Le-Phos (2019)
• TY-Phos (2020)
• GF-Phos (2021)
• W-Phos (2022)
• Rong-Phos (2023)

To date, Professor Zhang’s research group has published over 100 scientific articles in internationally recognized journals, solidifying the significance of the SadPhos family in asymmetric synthesis.

Spotlight on Xu-Phos: Exceptional Enantioselectivity

Among the SadPhos ligands, Xu-Phos, named after Dr. Xu Bing, has demonstrated outstanding enantioselectivity across 14 types of palladium-catalyzed asymmetric reactions. Its performance highlights its versatility and potential for advancing the field of asymmetric synthesis.

J&K Scientific offers a comprehensive selection of high-purity Xu-Phos ligands at competitive prices, with options for bulk packaging. Each batch undergoes rigorous quality control, verified through hydrogen nuclear magnetic resonance (NMR) and phosphorus spectroscopy, ensuring reliable results for researchers.

J&K Scientific is committed to providing high-quality products to support asymmetric synthesis, including:

• Extensive Range: A complete portfolio covering chiral ligands, metal catalysts, organic molecular catalysts, chiral building blocks, prosthetic groups, reagents, and separation tools.
• Innovative Solutions: Cutting-edge chiral ligands and catalysts based on the latest research in the field.
• Quality Assurance: High purity, strict quality control, and consistent batch quality to ensure reliable results.

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Product name：
[S(R)]-N-[(S)-][2-(Dicyclohexylphosphino) phenyl]phenylmethyl[S(R)]-N-[(S)-][2-(Dicyclohexylphosphino) phenyl]phenylmethyl