The Zhang Xiaobing-Yuan Lin research group at Hunan University has developed a new class of fluorescent dyes with high brightness, excellent photostability, and large Stokes shift—YueLu dyes (YLs). These dyes offer superior performance in protein labeling and super-resolution imaging, making them ideal for high signal-to-noise ratio protein visualization.

A key derivative, YL578-NHS, serves as an active intermediate for protein labeling, while YL578-Halo and 10-Halo probes enable high-resolution protein imaging.

Key Advantages of YueLu Dyes (YLs) Compared to Traditional Rhodamine Dyes

• Higher brightness
  • YLs: 66,400 M⁻¹ cm⁻¹
  • Classic Rhodamine Dyes: 32,500 M⁻¹ cm⁻¹
• Larger Stokes shift
  • YLs: 52 nm
  • Classic Rhodamine Dyes: 27 nm
• Superior photostability
  • YLs maintain fluorescence intensity for a significantly longer duration.
  • Enables 5x more frames in imaging compared to traditional probes before reaching half of the initial brightness.

These enhanced properties make YueLu dyes ideal for long-term, high-resolution bioimaging and protein tracking.

Applications of YueLu Dyes (YLs) in Super-Resolution Imaging

• High-contrast protein visualization for biomedical research.

• Long-term super-resolution imaging with minimal photobleaching.

• Superior imaging quality in complex biological environments due to a high signal-to-noise ratio.

J&K Scientific provides high-purity YueLu dyes and Halo protein labeling probes, ensuring precision and reliability in advanced imaging applications.

Figure 1 Comparison of performance between Yuelu dye and traditional rhodamine dye[1]

Professor Yuan Lin is a professor and doctoral supervisor at the School of Chemistry and Chemical Engineering, Hunan University and the State Key Laboratory of Chemical Biosensing and Metrology.Currently, he has published more than 100 papers in international academic journals, with a total citation of more than 12,000 times, and an h-index of 58.Among them, the first or corresponding author from 2012 to presentJ. Am. Chem. Soc.（10 articles）、 Nat. Commun.（1 articles）、 Angew. Chem. Int. Ed.（10 articles）、CCS Chem.（1 articles）、Chem. Sci.（4 articles）、Anal. Chem.（10 articles）、Adv. Funct. Mater、BiomaterialsPublished more than 70 papers in journals and other journals. Mainly engaged in research on small molecule fluorescent probes and their applications.

Product List

Product name：
YL578
CAS：N/A
Item number：9332511

Product name：
YL578-COOH
CAS：N/A
Item number：9332513

 

Product name：
YL578-CF3
CAS：N/A
Item number：9332514

 

Product name：
YL578-NHS
CAS：N/A
Item number：9332512

 

Product name：
YL578-CF3-Halo
CAS：N/A
Item number：9332517

Product name：
YL578-Halo
CAS：N/A
Item number：9332516

Product name：
YL578-COOH-NHS
CAS： N/A
Item number：9332515

References

1. Jiang, Gangwei , et al. "A synergistic strategy to develop photostable and bright dyes with long Stokes shift for nanoscopy." Nature Communications 13(2022).