Autophagy is an important cell signaling pathway related to many physiological and pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer. A common autophagy inhibitor is 3-Methyladenine (3-MA), which inhibits the formation of autophagosomes by inhibiting PI3K. Its concentration needs to be in the mM level each time.

The compound 3BDO developed by Professor Zhao Baoxiang of Shandong University is a high-efficiency autophagy inhibitor. Compared with 3-MA, 3BDO only needs a concentration of μM to inhibit autophagy, making it a powerful tool for studying autophagy. In addition, 3BDO is also an effective tool for studying mTOR kinase, which can target FKBP1A and activate the mTOR signaling pathway to inhibit autophagy in human umbilical vein endothelial cells (HUVECs) (Figure 1). It can also be used together with the compound Rapamycin as a research tool to analyze regulatory networks [1-2].

Figure 1 3BDO is an effective tool for studying mTOR kinase [1][1];
Stable supply of spot goods.

Peng N, et al. Sci Rep. 2014, 4, 5519.
Ge D, et al. Autophagy. 2014, 10(6), 957-971.

Product number：1914077

3BDO, 97%