Hyaluronan (HA) and chondroitin (CH) are two important glycosaminoglycans that are widely present on the cell surface and extracellular matrix. They can interact with cytokines, cell adhesion molecules, selectins, and enzymes to regulate intracellular signaling pathways [1]. At the same time, it is also widely used in medicine, cosmetics and other fields.
Currently, commercialized hyaluronic acid and chondroitin mainly rely on animal tissue extraction and microbial fermentation methods to prepare them [2]. Affected by the intrinsic control factors of polysaccharide synthesis in organisms, these polysaccharides are highly heterogeneous (molecular weight distribution range is wide and diffuse), hindering the correct characterization of biological functions.
Associate Professor Fang Junqiang from the Sugar Engineering Research Center of Shandong University used enzymatic method to synthesize HA/CH polysaccharide. The advantages are as follows:
Good uniformity: Product Dispersion Index (PDI) <1.5 (the closer the value is to 1, the better the uniformity);
Customizable molecular weight: A variety of uniform HA/CH polysaccharides and derivatives with different molecular weight requirements can be prepared according to scientific research needs.
Scientific research results of Associate Professor Fang Junqiang of Bailingwei Sales——HA/CH polysaccharide
Introduction to the research team: Fang Junqiang, male, PhD, associate professor and doctoral supervisor at the National Sugar Engineering Technology Research Center of Shandong University. The research directions are: 1. Research on modular enzymatic synthesis strategies of uniform glycosaminoglycans; 2. Chemical enzymatic synthesis and application of complex oligosaccharides; 3. Research on sugar nucleotide synthesis pathways and large-scale preparation.
Product list
9185393（degree of polymerization n=100）
950363（degree of polymerization n=500）
958159（degree of polymerization n=1000）
9185394（degree of polymerization n=100）
939226（degree of polymerization n=500）
922063（degree of polymerization n=1000）
向阳 翟
