Trifluoromethyl is an important structure. Introducing it into organic compounds can improve the polarity, dipole moment, stability, and lipophilicity of the target product. Therefore, compounds containing trifluoromethyl are widely used in medicines and pesticides. , new materials and other fields are of great significance. Methyl fluorosulfonyl difluoroacetate (also known as "Chen Qingyun's reagent" [1]) is a widely used economical and efficient trifluoromethylation reagent. Through this reagent, the first catalytic trifluoromethylation of organic halogenated compounds was achieved. chemical reaction.

Figure 1 Chen’s methodology fluoroalkylating reagents

Cu(O2CCF2SO2F)2
A new generation of trifluoromethylation reagent developed based on "Chen Qingyun Reagent";
Mild reaction: The traditional "Chen Qingyun reagent" reaction requires a certain temperature, but this copper salt can react at room temperature;
Wider application and more efficient: aromatic rings, heterocyclic rings, and SP3 bond structures can be applied;
High reactivity and high efficiency.

Ag(O2CCF2SO2F)
The application scope of Chen's method trifluoromethylation reagent is expanded to free radical trifluoromethylation reaction for the first time;
Make full use of the by-product sulfur dioxide and convert it into important sulfonyl fluoride groups;
For the first time, trifluoromethyl and fluorosulfonyl groups were simultaneously introduced into the molecule.