Alkaline phosphatase (ALP) is a hydrolase that is widely present in human liver and bones [1] . The ALP content in human serum is an important indicator for the diagnosis of liver diseases such as liver cancer and bone diseases, and has very important clinical significance [2-3].

The precipitation-type ALP fluorescent probe HTPQA has no fluorescence signal itself, but after reacting with ALP, it releases the highly hydrophobic and highly fluorescent HTPQ, which then rapidly precipitates to obtain bright orange-yellow solid-state fluorescence, enabling in-situ detection and imaging of ALP.

Bailingwei exclusively sells the HTPQA fluorescent probe developed by Professor Zhang Xiaobing:

High sensitivity: exhibits 116-fold fluorescence enhancement, and the lower detection limit is 1.36UL-1;
Fast response speed: avoids the shortcomings of easy diffusion of traditional fluorescent probes;
Good selectivity;
Suitable for detection of ALP enzyme in buffer solutions, living cells and tissues;
In live cell imaging, it exhibits diffusion-resistant ALP in situ imaging capabilities.

McComb, RobertB. Alkaline phosphatase [M]. Plenum Press, 1979.
de Vries, E. M., Wang, J., Leeflang, M. M., Boonstra, K., Weersma, R. K., & Beuers, U.. Liver International, 2016. 36(12), 1867-1875.
Waziri, B., Duarte, R., & Naicker, S. International Jouranl of Nephrology, 2017(13), 1-8.