Sugar nucleotides are formed by connecting the reducing end of a monosaccharide to the terminal phosphate group of a nucleoside diphosphate (or nucleoside monophosphate), and are the activated form of a monosaccharide. It can serve as a donor substrate for glycosyltransferases and participate in the enzymatic synthesis of complex oligosaccharides in vivo. Sugar nucleotides and their derivatives play a very important role in studying substrate recognition and other biochemical properties of glycosyltransferases. In addition, sugar nucleotide derivatives can be used for the synthesis of various sugar derivatives and can also be used as an emerging tool for targeted delivery of cell-specific ligands [1].
Associate Professor Fang Junqiang from the Sugar Engineering Research Center of Shandong University has developed a series of sugar nucleotides and their derivatives. The advantages are as follows:
Excellent quality: using a rapid purification strategy, the purity of the products obtained is ≥95%;
Full range: Contains 8 commonly used sugar nucleotides and 4 sugar nucleotide derivatives, covering the types of sugar donors required for the biosynthesis of glycosaminoglycans, Lewis antigens, human milk oligosaccharides, etc.;
Can be supplied in large quantities: It uses soluble expressed biological enzymes and is efficiently prepared by one-pot enzymatic reaction.
Scientific research results of Associate Professor Fang Junqiang of J&K Scientific Sales——Sugar nucleotides and their derivatives
Introduction to the research team: Fang Junqiang, male, PhD, associate professor and doctoral supervisor at the National Sugar Engineering Technology Research Center of Shandong University. The research directions are: 1. Research on modular enzymatic synthesis strategies of uniform glycosaminoglycans; 2. Chemical enzymatic synthesis and application of complex oligosaccharides; 3. Research on sugar nucleotide synthesis pathways and large-scale preparation.
Product list：
向阳 翟
