Nitrogen-containing compounds widely exist in natural products, drugs, functional materials and other fields, so the efficient construction of C-N bonds has attracted much attention. Traditionally, the formation of amide groups mainly relies on the homocleavage of N-X bonds, but N-X bonds are difficult to construct under harsh conditions, which fundamentally excludes the wide application of this method in the synthetic community.

Encouragingly, visible light-catalyzed reactions have received special attention due to their mild conditions. Based on redox, different groups are introduced on the oxygen atom of hydroxylamine to promote the generation of amino free radicals. However, their applications are limited due to inherent shortcomings such as the high cost of amination reagents, dependence on the redox potential of the substrate, and the participation of metal photocatalysts or sacrificial donors. Therefore, the development of new, readily available amination reagents will expand the boundaries of amide chemistry and provide new synthetic opportunities for direct amination. [1][1][1]

product information

Product name:

tert-Butyl (perchloropyridin-4-yl)oxycarbamate

CAS：2591503-08-9

Item number: 9200608

 参考文献

1. Lan Zheng, Yu-En Qian, Yuan-Zhuo Hu, Jun-An Xiao, Zhi-Peng Ye, Kai Chen, Hao-Yue Xiang,*Xiao-Qing Chen,* and Hua Yang*, Org. Lett. 2021, 23, 1643−1647.