Hexasubstituted benzene derivatives are a class of compounds with exceptional structural attributes, offering six derivatization sites. These compounds exhibit structural rigidity, high symmetry, abundant modification possibilities, and diverse topological configurations. Their unique properties make them invaluable in constructing functional supramolecular assemblies and dendrimers. Consequently, these derivatives are widely utilized in molecular design and the development of advanced functional materials.
In recent years, hexasubstituted benzene derivatives have garnered significant attention from researchers in fields such as supramolecular chemistry, materials science, environmental science, and energy research.
Supercapsules: Next-Generation Molecular Cages
Supercapsules are a distinctive type of molecular cage featuring two parallel benzene rings connected by six side chains. Unlike traditional supramolecular host compounds, supercapsules boast a lantern-like conformation with a (quasi) closed internal cavity and numerous recognition sites distributed around the structure.
Simple Synthesis: Achieved through classical nucleophilic and electrophilic reactions under mild conditions.
Diverse Structures: Act as a universal functional molecular platform, enabling the creation of various functional molecular systems via pre-modification and post-derivatization functionalization.
Unique Properties: Provide exceptional binding abilities and ultra-high selectivity due to their (quasi) closed structures and multiple recognition sites.
Wide Applications: Suitable for constructing dendrimers, polymers, supramolecular assemblies, and advanced functional materials. They also enable innovations in molecular recognition, bioimaging, medical diagnostics, targeted drug delivery, and gas separation.
J&K Scientific offers products derived from the groundbreaking research of Professor He Qing's group. These include supercapsules and hexasubstituted benzene derivatives, which are instrumental in advancing research in supramolecular chemistry and functional material development.
In recent years, hexasubstituted benzene derivatives have garnered significant attention from researchers in fields such as supramolecular chemistry, materials science, environmental science, and energy research.
Supercapsules: Next-Generation Molecular Cages
Supercapsules are a distinctive type of molecular cage featuring two parallel benzene rings connected by six side chains. Unlike traditional supramolecular host compounds, supercapsules boast a lantern-like conformation with a (quasi) closed internal cavity and numerous recognition sites distributed around the structure.
These features make supercapsules highly versatile:
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Functional Materials: Applicable in gas separation, CO₂ capture, and targeted drug delivery.
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Supramolecular Subjects: Serve as molecular or ion cages for neutral molecules (e.g., xenon, methane) and ions, enabling encapsulation, protection, and transportation.
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Molecular Containers: Provide advanced platforms for studying water clusters, solvent clusters, and ionic solvent clusters.
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Optical Applications: Exhibit unique liquid and solid fluorescence properties, offering potential in bioimaging, integrated diagnosis and treatment, nonlinear optical materials, and circularly polarized luminescence (CPL) materials.
Simple Synthesis: Achieved through classical nucleophilic and electrophilic reactions under mild conditions.
Diverse Structures: Act as a universal functional molecular platform, enabling the creation of various functional molecular systems via pre-modification and post-derivatization functionalization.
Unique Properties: Provide exceptional binding abilities and ultra-high selectivity due to their (quasi) closed structures and multiple recognition sites.
Wide Applications: Suitable for constructing dendrimers, polymers, supramolecular assemblies, and advanced functional materials. They also enable innovations in molecular recognition, bioimaging, medical diagnostics, targeted drug delivery, and gas separation.
J&K Scientific offers products derived from the groundbreaking research of Professor He Qing's group. These include supercapsules and hexasubstituted benzene derivatives, which are instrumental in advancing research in supramolecular chemistry and functional material development.
Figure 1 Chaofan before and after functionalization[2]
Hexasubstituted benzene derivatives
Product name：
Hexakis(bromomethyl)benzene, 99%
CAS：3095-73-6
Item number：612080
Hexakis(bromomethyl)benzene, 99%
CAS：3095-73-6
Item number：612080
Product name：
1,2,3,4,5,6-Hexa(hydroxymethyl)benzene, 98%
CAS：2715-91-5
Item number：2041123
1,2,3,4,5,6-Hexa(hydroxymethyl)benzene, 98%
CAS：2715-91-5
Item number：2041123
Product name：
1,2,3,4,5,6-Hexa(aminomethyl)benzene, 98%
CAS：1019338-69-2
Item number：9272175
1,2,3,4,5,6-Hexa(aminomethyl)benzene, 98%
CAS：1019338-69-2
Item number：9272175
Product name：
1,2,3,4,5,6-Hexakis(azidomethyl)benzene, 98%
CAS：107864-70-0
Item number：9272176
1,2,3,4,5,6-Hexakis(azidomethyl)benzene, 98%
CAS：107864-70-0
Item number：9272176
Product name：
1,2,3,4,5,6-Benzenehexamethanamine, hydrochloride, 98%
CAS：2243214-03-9
Item number：9372475
1,2,3,4,5,6-Benzenehexamethanamine, hydrochloride, 98%
CAS：2243214-03-9
Item number：9372475
Product name：
1,2,3,4,5,6-Benzenehexamethanethiol
CAS：62469-17-4
Item number：9372476
1,2,3,4,5,6-Benzenehexamethanethiol
CAS：62469-17-4
Item number：9372476
Product name：
1,2,3,4,5,6-Hexa(Hydroxylaminemethylene)benzene, 95%
CAS：N/A
Item number：9372477
1,2,3,4,5,6-Hexa(Hydroxylaminemethylene)benzene, 95%
CAS：N/A
Item number：9372477
Product name：
1,3,5-Trichlorotrinitrobenzene, 95%
CAS：2631-68-7
Item number：1015830
1,3,5-Trichlorotrinitrobenzene, 95%
CAS：2631-68-7
Item number：1015830
Product name：
(2,4,6-Trimethoxybenzene-1,3,5-triyl)trimethanamine, 98%
CAS：1001404-25-6
Item number：9372479
(2,4,6-Trimethoxybenzene-1,3,5-triyl)trimethanamine, 98%
CAS：1001404-25-6
Item number：9372479
Superfan Compounds
Product name：
Hexapyridinyldodecaazasuperphane, 95%, single crystals
Item number：9272177
Hexapyridinyldodecaazasuperphane, 95%, single crystals
Item number：9272177
Product name：
Hexaphenyldodecaazasuperphane, 95%, single crystals
Item number：9272178
Hexaphenyldodecaazasuperphane, 95%, single crystals
Item number：9272178
Product name：
Hexaoxadibenzenedodecaazasuperphane, 95%
Item number：9372482
Hexaoxadibenzenedodecaazasuperphane, 95%
Item number：9372482
Product name：
Hexafuranyldodecaazasuperphane, 95%
Item number：9372480
Hexafuranyldodecaazasuperphane, 95%
Item number：9372480
References
- Zhou W, Li A, Gale P A, et al. A highly selective superphane for ReO4− recognition and extraction[J][J][J][J]. Journal of the American Chemical Society, 2021, 143(10): 3874-3880.
- A superphanes compound and its preparation method and application. CN202110929467.4
Vicky Zhao
