On February 26, 2022, the team of Academicians Feng Xiaoming and Wu Yundong, titled "Asymmetric Catalytic (2+1) Cycloaddition of Thioketones to Synthesize Tetrasubstituted Thiiranes", presented at Angew. Chem. Int. Ed. published the latest research results. In the article, "Feng's ligand" was selected to catalyze α-diazopyrazole amide and thione to perform an asymmetric (2+1) cycloaddition reaction to obtain four-substituted episulfide propane compounds, see Figure 1, and further generates tetra-substituted alkenes with high cis-to-trans ratio through derivatization [1]. This discovery solved the industry problem of difficult to control stereoselectivity in the synthesis of tetra-substituted episulfide propane compounds, opened up a new synthesis route, and the reaction process was rapid and efficient. The "Feng's ligand" once again played an important role.
Figure 1. "Fon's ligand" catalyzes the reaction to synthesize tetratriethyl episulfide compounds (for example: 1595283, 1595285)
"Feng's ligand" is a chiral dinitroxide metal complex, which is formed from a chiral dinitroxide compound and more than 20 kinds of metal ion ligands such as main group metals, rare earth metals or transition metals. It has a unique three-dimensional electronic structure. It can catalyze more than 70 types of asymmetric reactions with high efficiency and selectivity (including more than 10 types of challenging and previously unachievable asymmetric catalytic new reactions, achieving a breakthrough from 0 to 1). "Feng's ligand" effectively solves industry problems and is widely used in medicine, pesticides, cosmetics, food additives and other fields, providing new ideas and breakthroughs for my country's research on asymmetric catalysis and chiral compound synthesis. Academician Feng Xiaoming has devoted many years of research and achieved fruitful results. He has won many honors such as the "Future Science Award for Physical Science", the "Ho Leung Ho Lee Foundation Science and Technology Progress Award", and the "Tan Kah Kee Science Award - Chemical Science Award".
"Feng's ligand" has obvious advantages:
Modifiable and tunable, it is widely applicable to asymmetric organic reactions.
The reaction conditions are mild, the process is rapid and efficient, the yield is high, and there are almost no by-products.
The price is cheap and the physical and chemical properties are stable, which reduces the production cost of enterprises.
Exclusively supplied by Bailingwei, high purity, various packaging specifications, sufficient stock.
Feng's Ligand Piperidine Framework Product List
NO-Feng-PCyPPi
References
- Xiaobin Lin, Maoping Pu, Xinpeng Sang, Shiyang Li, Xiaohua Liu*, Yun-dong Wu*, Xiaoming Feng*. Angew.Chem.Int.Ed.,2022, DOI:10.1002/anie.202201151
向阳 翟
