3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α;,9S)-10,11-dihydro-6'-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, 98%, (99% ee)|07-7029|1352957-59-5

3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α;,9S)-10,11-dihydro-6'-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, 98%, (99% ee)

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Product Information

Product Name
3-3,5-Bis(trifluoromethyl)phenylamino-4-(8α;,9S)-10,11-dihydro-6'-methoxycinchonan-9-ylamino-3-cyclobutene-1,2-dione, 98%, (99% ee)
Brand Name
US-Strem
Product Number
07-7029
CAS
1352957-59-5
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
57327662
IUPAC Name
3-3,5-bis(trifluoromethyl)anilino-4-(S)-(2S,4S,5R)-5-ethyl-1-azabicyclo2.2.2octan-2-yl-(6-methoxyquinolin-4-yl)methylaminocyclobut-3-ene-1,2-dione
InChI Key
OFXKFCTYZMFMJB-FRSFCCSCSA-N
SMILES
CCC@H1CN2CCC@H1CC@H2C@H(C3=C4C=C(C=CC4=NC=C3)OC)NC5=C(C(=O)C5=O)NC6=CC(=CC(=C6)C(F)(F)F)C(F)(F)F

Application

Technical Notes:
1.Michael Addition: The enantioselective tandem Michael addition reaction of dimedone and related 1 ,3- dicarbonyI compounds with a, ß-unsaturated N-acylated succinimides catalyzed by a chiral squaramide catalyst has been investigated. References：
1. Tetrahedron: Asymmetry, 2014, 25, 310-317.

References

Cytotoxicity of cinchona alkaloid organocatalysts against MES-SA and MES-SA/Dx5 multidrug-resistant uterine sarcoma cell lines
Publication Name: Bioorganic & Medicinal Chemistry
Publication Date: 2022-08-01
DOI: 10.1016/j.bmc.2022.116855

Enantioselective Organocatalytic Michael Addition of Cyclopentane-1,2-diones to Nitroolefins
Publication Name: Synthesis
Publication Date: 2014-07-15
DOI: 10.1055/s-0034-1378374