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Sku SC07-5611_50_MG
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Product Information

Product Name
3-3,5-Bis(trifluoromethyl)phenylamino-4-(1S,2S)-2-(1-pyrrolidinyl)cyclohexylamino-3-cyclobutene-1,2-dione, 98%, (99% ee)
Brand Name
US-Strem
Product Number
07-5611
CAS
1346683-42-8
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
127256048
IUPAC Name
3-3,5-bis(trifluoromethyl)anilino-4-(1S,2S)-2-pyrrolidin-1-ylcyclohexylaminocyclobut-3-ene-1,2-dione
InChI Key
CRIYFAISGRLYEW-HOTGVXAUSA-N
SMILES
C1CCC@@H(C@H(C1)NC2=C(C(=O)C2=O)NC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCCC4

Application

Technical Notes:
1.Mannich Reaction: The asymmetric addition of the present HWE reagents to N-ca rbamoyl imines
generated in situ was achieved. The corresponding Mannich adducts can be further transformed to aza- MBH type products in good to excellent enantioselectivities.
References:
1. Chem. Sci., 2011, 2, 1918-1921.