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3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(1S,2S)-2-(1-piperidinyl)cyclohexyl]amino]-3-cyclobutene-1,2-dione, 95%, (99% ee)|07-1423|1312991-15-3

3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(1S,2S)-2-(1-piperidinyl)cyclohexyl]amino]-3-cyclobutene-1,2-dione, 95%, (99% ee)

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Sku SC07-1423_100_MG
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Product Information

Product Name
3-3,5-Bis(trifluoromethyl)phenylamino-4-(1S,2S)-2-(1-piperidinyl)cyclohexylamino-3-cyclobutene-1,2-dione, 95%, (99% ee)
Brand Name
US-Strem
Product Number
07-1423
CAS
1312991-15-3
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
66559351
IUPAC Name
3-3,5-bis(trifluoromethyl)anilino-4-(1S,2S)-2-piperidin-1-ylcyclohexylaminocyclobut-3-ene-1,2-dione
InChI Key
XUZPZFXQOUOXFH-IRXDYDNUSA-N
SMILES
C1CCN(CC1)C@H2CCCCC@@H2NC3=C(C(=O)C3=O)NC4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F

Description

Technical Notes:
1.An efficient diastereo- and enantioselective Michael addition of 3-substituted oxindoles onto nitroalkenes catalyzed by a bifunctional chiral squaramide catalyst has been developed.
2.An efficient chiral squaramide catalysed enantiosele ctive Michael addition of pyrazolin-5-ones to
nitroalkenes has been developed.
3.An efficient asymmetric cascade sulfa-Michael/Michael addition reaction catalyzed by a chiral bifunctional squaramide-tertiary amine catalyst has been developed.
4.A highly enantio- and diastereoselective sulfa-Michael addition of thioacetic acid to a,ß-disubstituted nitroalkenes catalysed by a chiral squaramide organocatalyst has been described.

References Data Source From Pubchem

Synthesis from Thiocarboxylic Acids by Addition Reactions
Publication Name: Science of Synthesis
Publication Date: 2024

Asymmetric Synthesis of Tetrahydrobenzofurans and Annulated Dihydropyrans via Cooperative One-Pot Organo- and Silver-Catalysis
Publication Name: Synthesis
Publication Date: 2016-06-23
DOI: 10.1055/s-0035-1561468

Enantioselective Michael Addition of Pyrazolin-5-ones to β-CF3-β-Disubstituted Nitroalkenes Catalyzed by Squaramide Organocatalyst
Publication Name: Synlett
Publication Date: 2016-06-01
DOI: 10.1055/s-0035-1561460

Recent Advances in Organocatalytic Cascade Reactions toward the Formation of Quaternary Stereocenters
Publication Name: Synthesis
Publication Date: 2015-07-14
DOI: 10.1055/s-0034-1378742

Chiral Squaramide Catalyzed Benzyl Thiol Synthesis via ortho-Quinone Methides
Publication Name: Synfacts
Publication Date: 2015-04-17
DOI: 10.1055/s-0034-1380579