1,1'-Bis(diphenylphosphino)ferrocene palladium(II)chloride dichloromethane complex, 97%

🧑‍🔬 Catalyzing Cross-Coupling Reactions
This is its most central application. It is extensively used to catalyze a variety of cross-coupling reactions that form carbon-carbon and carbon-heteroatom bonds, making it an indispensable tool for constructing complex organic molecules.

• Suzuki-Miyaura Coupling: Catalyzes the coupling of arylboronic acids with aryl halides, serving as one of the most important methods for synthesizing biaryl compounds, which are common structures in pharmaceuticals and materials.

• Stille Coupling: Catalyzes the coupling of organotin compounds with halides.

• Negishi Coupling: Catalyzes the coupling of organozinc compounds with halides.

• Buchwald-Hartwig Amination: Catalyzes the coupling of aryl halides with amines, a key method for constructing arylamine compounds used in the synthesis of drugs and materials.

🧪 Other Catalytic Transformations
Beyond the coupling reactions mentioned above, Pd(dppf)Cl₂ is also an effective catalyst for various other transformations.

• Borylation of Aryl Halides: Introduces boronate ester groups onto aromatic rings, providing precursors for further coupling reactions.

• Carbonylation Reactions: Catalyzes reactions that introduce carbonyl groups.

• Domino/Tandem Reactions: Used for the one-step construction of complex polycyclic molecules, such as in the synthesis of polyheterocycles.

⚛️ Synthetic Building Block and Ligand Precursor
The compound itself is a stable, well-defined organometallic complex. It can serve as a precursor to generate the actual catalytically active zero-valent palladium species (Pd(0)) in situ, or as a source of the bisphosphine ligand (dppf). Researchers also utilize its well-defined structure for spectroscopic studies to investigate catalytic reaction mechanisms

Q1: What is CAS 95464-05-4?

A: CAS 95464-05-4 is [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) Dichloromethane Adduct, commonly written as PdCl₂(dppf)·CH₂Cl₂.

Q2: What is PdCl₂(dppf)·CH₂Cl₂?

A: It is a palladium(II) complex containing the chelating dppf ligand and dichloride ligands, with one molecule of dichloromethane incorporated as a 1:1 adduct.

Q3: What is the molecular weight of CAS 95464-05-4?

A: The molecular weight is 816.64 g/mol.

Q4: What is the molecular formula?

A: The molecular formula is C₃₅H₃₀Cl₄FeP₂Pd, corresponding to the dppf-palladium dichloride complex with one molecule of dichloromethane.

Q5: What is PdCl₂(dppf)·CH₂Cl₂ used for?

A: It is mainly used as a palladium catalyst or catalyst precursor for cross-coupling reactions, particularly in synthetic organic and pharmaceutical chemistry.

Q6: Is it the same as PdCl₂(dppf)?

A: Not exactly. CAS 95464-05-4 is the dichloromethane adduct, written as PdCl₂(dppf)·CH₂Cl₂. The dichloromethane-free complex is a distinct material and should not be assigned the same CAS number.

Q7: What is dppf?

A: dppf stands for 1,1′-bis(diphenylphosphino)ferrocene, a bidentate phosphine ligand widely used in transition-metal catalysis.

Q8: How should CAS 95464-05-4 be stored?

A: Store the material tightly closed in a cool, dry environment and protect it from moisture and contamination. Product-specific storage recommendations should always be followed.