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3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, 98%, (99% ee)|07-1356|1211565-08-0

3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, 98%, (99% ee)

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Sku SC07-1356_50_MG
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Product Information

Product Name
3-(1R,2R)-2-(1-Piperidinyl)cyclohexylamino-4-4-(trifluoromethyl)phenylamino-3-cyclobutene-1,2-dione, 98%, (99% ee)
Brand Name
US-Strem
Product Number
07-1356
CAS
1211565-08-0
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
44817278
IUPAC Name
3-(1R,2R)-2-piperidin-1-ylcyclohexylamino-4-4-(trifluoromethyl)anilinocyclobut-3-ene-1,2-dione
InChI Key
JRSCPJJNZMRAQS-IAGOWNOFSA-N
SMILES
C1CCN(CC1)C@@H2CCCCC@H2NC3=C(C(=O)C3=O)NC4=CC=C(C=C4)C(F)(F)F

Description

Technical Notes:
1.Macheal Addition- highly enantioselective Michael addition reaction of diphenyl phosphite to a range of nitroalkenes .
2.Hydrophosphonylation- diphenylphosphite has been successfully employed in a chiral Pudovik reaction with aldehydes, extending the generality of this asymmetric methodology.
3.Friedel-Crafts/Substitution Domino Reaction- Dihydroarylfuran skeletons are efficiently synthesized from (Z)- bromonitroalkenes and naphthol derivatives in good yields and excellent enantioselectivities
References:
1.Angew. Chem. Int. Ed., 2010, 49, 153-1 56. 2.Org. Biomol. Chem., 2014, 12, 1258-1264.
3.Angew. Chem. Commun., 2013, 49, 2001-2003.

References Data Source From Pubchem

Stereoselective Domino Reactions in the Synthesis of Spiro Compounds
Publication Name: Synthesis
Publication Date: 2022-05-16
DOI: 10.1055/a-1771-0641

Recent Progress towards Organocatalyzed Asymmetric (Hetero)Arene Formation
Publication Name: Synthesis
Publication Date: 2020-10-28
DOI: 10.1055/s-0040-1707327

Synthesis of Furan Atropisomers by Central-to-Axial Chirality Conversion
Publication Name: Synfacts
Publication Date: 2017-03-17
DOI: 10.1055/s-0036-1590089

Amine Thiourea Catalysed Double Michael Reaction: An Approach for the Asymmetric Synthesis of Spiro[pyrazolone-4,3′-tetrahydrothiophenes]
Publication Name: Synthesis
Publication Date: 2017-02-21
DOI: 10.1055/s-0036-1588725

Asymmetric Synthesis of Rauhut–Currier-type Products by Bifunctional Catalysis
Publication Name: Synfacts
Publication Date: 2017-02-15
DOI: 10.1055/s-0036-1590008