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(2S)-2-[[[[(1R,2R)-2-Aminocyclohexyl]amino]thioxomethyl]amino]-N,3,3-trimethyl-N-(phenylmethyl)butanamide, 98%, (99% ee)|07-0956|479423-21-7

(2S)-2-[[[[(1R,2R)-2-Aminocyclohexyl]amino]thioxomethyl]amino]-N,3,3-trimethyl-N-(phenylmethyl)butanamide, 98%, (99% ee)

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Sku SC07-0956_50_MG
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Product Information

Product Name
(2S)-2-(1R,2R)-2-Aminocyclohexylaminothioxomethylamino-N,3,3-trimethyl-N-(phenylmethyl)butanamide, 98%, (99% ee)
Brand Name
US-Strem
Product Number
07-0956
CAS
479423-21-7
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
57332980
IUPAC Name
(2S)-2-(1R,2R)-2-aminocyclohexylcarbamothioylamino-N-benzyl-N,3,3-trimethylbutanamide
InChI Key
CNEVMNSDRMDKFO-KZNAEPCWSA-N
SMILES
CC(C)(C)C@@H(C(=O)N(C)CC1=CC=CC=C1)NC(=S)NC@@H2CCCCC@H2N

Description

Technical Notes:
1.Conjugate Addition: Primary amine -thiourea derivative is an active and highly enantioselective catalyst for the conjugate addition of ketones to nitroalkenes.
2.Michael Addition: The asymmetric Michael addition of dioxindoles to ß-substituted nitroalkenes is reported. The bifunctional primary amine-thiourea, by means of a non-covalent-based mode of catalysis, secures
direct access to 3-substituted 3-hydroxyoxindole derivatives with high stereocontrol.
References:
1. J. Am. Chem. Soc., 2006, 128, 7170-7171. 2. Chem. Commun., 2012, 48, 3336-3338.

References Data Source From Pubchem

Total Synthesis of (+)-Madangamine E
Publication Name: Synfacts
Publication Date: 2022-03-18
DOI: 10.1055/s-0041-1737927

Enantioselective Functionalization of Prochiral Cyclobutanones and Cyclobutenones
Publication Name: Synlett
Publication Date: 2021-05-25
DOI: 10.1055/a-1493-9489

Application of Nitrones for the Asymmetric Synthesis of Substituted Piperidines
Publication Name: Synfacts
Publication Date: 2018-11-19
DOI: 10.1055/s-0037-1611333

Intramolecular Desymmetrization of Cyclohexanones by Enamine Catalysis
Publication Name: Synfacts
Publication Date: 2015-04-17
DOI: 10.1055/s-0034-1380583

Enantioselective Organocatalyzed Desymmetrization of 3-Substituted Cyclobutanones through Michael Addition to Nitroalkenes
Publication Name: Synlett
Publication Date: 2014-11-11
DOI: 10.1055/s-0034-1379489