What is Chromatography? Chromatography is a fundamental technique in analytical chemistry used to separate the various components of a mixture. Imagine a container filled with different colored dyes. Separating these dyes manually is a complex task, but chromatography provides an elegant solution, similar to a sorting machine that uses the...

G-quadruplex (G4) fluorescent probes provide ideas for broadening viromics research on functional nucleic acids and developing new HCV infection detection. However, the traditional G4 dye has poor ability to cross cell membranes and is difficult to be directly used for live cell imaging.Hunan University's Nie Zhou team developed a new...

The basic building blocks of biomimetic homopolypeptides are protected or unprotected glutamic acid or lysine residues, which are obtained through ring-opening polymerization of cyclic amino acid anhydrides. They can be used in the field of biomedicine as drug delivery, gene delivery carriers or degradable biomimetic medical materials [1-2]. They can...

Click Chemistry is a synthesis concept proposed by Sharpless, a Nobel Prize winner in chemistry from the United States, in 2001 [1]. Among them, the main and classic click chemical reaction is the Cu(I)-catalyzed azide-alkynyl Husigen cycloaddition reaction (CuAAC). This reaction has the advantages of high yield, few side reactions,...

5-methylcytosine modification (5mC) is one of the important epigenetic modifications in eukaryotic cell genomes. 5mC can be gradually oxidized under the action of TET family enzymes to generate 5-hydroxymethylcytosine (5hmC), 5-aldehydecytosine (5fC) and 5-carboxycytosine (5caC); for the above-mentioned several new DNA modifications Functional research is currently a hot spot in...

Polyamide-amine (PAMAM) polymer materials are a type of highly branched, "all-rounder" dendrimers with specific three-dimensional structures and highly controllable molecular size and configuration. Its unique molecular structure and physical and chemical properties make it widely used in biomedicine sustained release, genetic material carrier, surfactant, environmental pollution treatment, etc. It is...