NIRII-HDs fluorescent dyes (Figure 1), developed by the Zhang Xiaobing-Yuan Lin research group, are designed for near-infrared II (NIR-II) region imaging. Compared to near-infrared I (NIR-I) and visible light, NIR-II dyes provide deeper tissue penetration and lower spontaneous background fluorescence, making them highly effective for in vivo imaging applications. These...

Two-photon imaging is a powerful technique in biomedical research and clinical diagnostics, offering deeper tissue penetration and reduced photodamage. The most commonly used two-photon dyes are electron donor-acceptor (D–A) type molecules, but their application is often hindered by solvation quenching effects, leading to reduced fluorescence efficiency. To overcome this challenge,...

The TPQL-1 and TPQL-2 fluorescent dyes, developed by the Zhang Xiaobing-Yuan Lin research group at Hunan University, are innovative two-photon dyes designed through a single-atom substitution and electron acceptor combination strategy based on the 6-ethyl-2-dimethylaminonaphthalene (acedan) structure (Figure 1). [1] In recent years, two-photon fluorescent dye imaging has gained widespread...

The Zhang Xiaobing-Yuan Lin research group at Hunan University has developed a new class of fluorescent dyes with high brightness, excellent photostability, and large Stokes shift—YueLu dyes (YLs). These dyes offer superior performance in protein labeling and super-resolution imaging, making them ideal for high signal-to-noise ratio protein visualization. A key...

Fluorine is a vital non-metal element widely used in pharmaceuticals and agrochemicals. Due to its unique electronegativity, electronic effects, and steric hindrance, fluorine atoms are often introduced into drug molecules to enhance metabolic stability, permeability, and bioavailability. Over 20% of commercially available drugs and pesticides contain one or more fluorine...

Achieving specificity in catalytic reactions by mimicking the active sites and substrate-binding cavities of enzymes is a significant scientific challenge. Professor Fang Yu's research group at Hunan University has developed an innovative supramolecular photocatalytic material, PCC-6-M, based on phenothiazine and octahedral porous coordination cages. This material enables the regulation of...