Sulfur-containing compounds occupy a very important position in the fields of food science, life science, pharmaceutical science, and materials science. However, the synthesis of sulfur-containing compounds presents many challenges [1]:Traditional methods of preparing sulfur-containing compounds use mercaptans and thiophenols, which not only have an unpleasant odor, but also often deactivate...

Ligands can bond with metal central atoms through coordination or covalent bonds, directly affecting the chemical environment around metal atoms, thereby improving reaction conditions, catalytic activity and conversion rates. So far, scientists have developed Thousands of chiral ligands. Among them, chiral oxazoline ligands have the advantages of diverse structures, easy...

Chemical cross-linking coupled with mass spectrometry (CXMS) is widely used in protein interaction analysis, structure identification and kinetic studies. However, there are fewer types of cross-linking agents available for CXMS, which mainly target protein N-termini and lysine residues, resulting in limited structural information that this technology can provide.Arginine is abundant...

Peroxynitrite anion (ONOO-) plays a key regulatory role in many physiological processes and is closely related to the occurrence of oxidative damage, ischemic stroke, neurodegenerative diseases, cancer and other diseases.In order to explore the biological mechanism of ONOO- in disease occurrence, it is particularly critical to find a method that...

Chromones and their derivatives are ubiquitous in natural products. This heterocyclic compound shows a variety of pharmacological properties and is one of the important frameworks for drug development. So far, scientists have synthesized a variety of functionalized chromones, especially C3-functionalized chromones. Studies have shown that 3-aminochromone has biological activities such...

In 2016, Professor Hong Xuechuan of Wuhan University published an article in the journal Nature Materials [1], successfully synthesizing for the first time a near-infrared fluorescence II region that can be used to label a variety of biomolecules and can be metabolized by organisms ( NIR-II) small molecule dye -...