Peroxynitrite anion (ONOO-) plays a key regulatory role in many physiological processes and is closely related to the occurrence of oxidative damage, ischemic stroke, neurodegenerative diseases, cancer and other diseases.In order to explore the biological mechanism of ONOO- in disease occurrence, it is particularly critical to find a method that...

Chromones and their derivatives are ubiquitous in natural products. This heterocyclic compound shows a variety of pharmacological properties and is one of the important frameworks for drug development. So far, scientists have synthesized a variety of functionalized chromones, especially C3-functionalized chromones. Studies have shown that 3-aminochromone has biological activities such...

According to statistics, more than two-thirds of human proteins can be phosphorylated. The huge signaling network composed of these phosphorylation sites provides important information for people to evaluate the physiological status of cells, identify disease markers, and discover drug targets. Therefore, phosphoproteomics is a very important direction in current protein...

In 2016, Professor Hong Xuechuan of Wuhan University published an article in the journal Nature Materials [1], successfully synthesizing for the first time a near-infrared fluorescence II region that can be used to label a variety of biomolecules and can be metabolized by organisms ( NIR-II) small molecule dye -...

Core Reagents for Biochemical Diagnostics: Enabling Trusted Test Results Biochemical diagnostics involves enzyme reactions or antigen-antibody interactions, primarily used to measure biochemical indicators, body function markers, and various proteins like enzymes, sugars, lipids, non-protein nitrogen, and inorganic elements. This method is essential in detecting and monitoring various medical conditions. As the...

FM Series Fluorescent Dyes for High-Specificity Cell Membrane Labeling and Neuronal Tracking The FM series fluorescent dyes, including FM 1-43, FM 2-10, FM 5-95, and FM 4-64, are lipophilic styrene-based dyes known for their non-toxic nature and specific application in labeling living cell membranes. These dyes are especially effective in...