The Friedel-Crafts alkylation reaction uses a Lewis acid catalyst to attach an alkyl group to an electron-rich benzene ring or derivative. First, a carbocation electrophile is generated through Lewis acid-assisted ionization of an alkyl halide. The aromatic ring then attacks the carbocation, forming a carbon-carbon bond and a new carbocation...

  The separation of ionic and ionizable analytes can be effectively achieved using a reversed-phase high performance liquid chromatographic (RP-HPLC) technique called ion-pair chromatography (IPC).  Used on reversed phase columns which are more efficient than columns used in ion exchange chromatography, resulting in better resolution  Sharper peak shapes and highly reproducible...

Ion-pair reagents (IPR) are used in reversed-phase liquid chromatography (RP-LC) and has effectively separated ionic or ionizable analytes.  Successful applications of Ion-pair Reagents Single- and double- stranded RNA / biological or synthetic (2011) [1] Stationary Phase: Non-porous polymeric columns and monolithic polymeric capillary columns Ion-Pair Reagent: Various traditional or volatile amine cation salts Detector: Fluorescent-based...

A major challenge in the development of a chromatographic method is the rational selection of experimental conditions that can provide adequate resolution in a reasonable run time. To increase the retention of ionic and polar analytes with a reversed phase column, it is important to choose an oppositely charged ion-pair...

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     Biological Activity For double-stranded DNA (ds-DNA) repair templates, RS-1 stimulates the binding of human HDR protein RAD51 (hRAD51) to cleavage-induced single-stranded DNA (ss-DNA) over-hangs, which enhances HDR proficiency by facilitating the formation of active presynaptic filaments and stabilizing ss-DNA-RAD51 nucleoprotein filaments, without inhibiting hRAD51 ATPase activity. [ 1 ]...