The Friedel-Crafts alkylation reaction uses a Lewis acid catalyst to attach an alkyl group to an electron-rich benzene ring or derivative. First, a carbocation electrophile is generated through Lewis acid-assisted ionization of an alkyl halide. The aromatic ring then attacks the carbocation, forming a carbon-carbon bond and a new carbocation...

The separation of ionic and ionizable analytes can be effectively achieved using a reversed-phase high performance liquid chromatographic (RP-HPLC) technique called ion-pair chromatography (IPC).  Used on reversed phase columns which are more efficient than columns used in ion exchange chromatography, resulting in better resolution  Sharper peak shapes and highly reproducible results even...

Ion-pair reagents (IPR) are used in reversed-phase liquid chromatography (RP-LC) and has effectively separated ionic or ionizable analytes.  Successful applications of Ion-pair Reagents Single- and double- stranded RNA / biological or synthetic (2011) [1] Stationary Phase: Non-porous polymeric columns and monolithic polymeric capillary columns Ion-Pair Reagent: Various traditional or volatile amine cation salts Detector: Fluorescent-based...

A major challenge in the development of a chromatographic method is the rational selection of experimental conditions that can provide adequate resolution in a reasonable run time. To increase the retention of ionic and polar analytes with a reversed phase column, it is important to choose an oppositely charged ion-pair...

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     Biological Activity For double-stranded DNA (ds-DNA) repair templates, RS-1 stimulates the binding of human HDR protein RAD51 (hRAD51) to cleavage-induced single-stranded DNA (ss-DNA) over-hangs, which enhances HDR proficiency by facilitating the formation of active presynaptic filaments and stabilizing ss-DNA-RAD51 nucleoprotein filaments, without inhibiting hRAD51 ATPase activity. [ 1 ]...