The study of protein phosphorylation (Figure 1) is called phosphoproteomics and is one of the important post-translational modification (PTM) methods in protein research, which mainly occurs on serine, threonine and tyrosine residues. This kind of PTM plays an important role in almost all cell signal transduction pathways, and at least...

The traditional way of connecting nucleic acids and antibodies mainly relies on the modification and reconnection of chemical coupling agents, such as azidating the sugar chain at the Fc end of the antibody, and then performing a coupling reaction with the DBCO-modified nucleic acid at the 5' end to complete...

More than 170 million people worldwide are infected with hepatitis C virus (HCV), a single-stranded positive-strand RNA virus. Once the human body is infected, it is very likely to develop diseases such as chronic hepatitis, cirrhosis and even liver cancer. Currently, the commonly used methods for detecting HCV infection in...

Polyethylene glycol functional chain compounds can modify the surface of proteins or substances and are used in the study of covalent macromolecule proteins, serving as connecting arms while enhancing the functional properties of proteins. For example: Adding polyethylene glycol to the protein modification improves the water solubility of the protein,...

In addition to the four common bases, DNA also has various chemical modifications, such as cytosine methylation modification, hydroxymethylation modification, aldehyde modification, adenine methylation modification, etc.Deoxyuracil (dU) is a DNA modified base, which can be formed from cytosine-amidamidine under the action of deaminase or from the misincorporation of dUMP during...

Polysulfamide is a linear polymer with selective metal (palladium) adsorption capacity. The research group of Professor Yi Wenbin of Nanjing University of Science and Technology has developed a general method for preparing polysulfamide using secondary amines, and uses palladium to assist the synthesis of polysulfamide. A palladium-crosslinked polysulfamide skeleton metal...