Trifluoromethyldiazomethane (CF₃CHN₂) is a crucial precursor for introducing trifluoromethyl groups into organic molecules, widely applied in organic synthesis. Despite its importance, traditional production methods present significant challenges in storage, safety, and handling risks (see Figure 1). To solve these issues, Professor Bi Xihe’s research group at the School of Chemistry,...

In organic synthesis, sulfur dioxide (SO₂) is a crucial reagent, but commonly used SO₂-releasing compounds come with significant limitations: Sodium sulfite (Na₂SO₃): Requires concentrated sulfuric acid, generating excessive heat. Sodium metabisulfite (Na₂S₂O₅) & potassium metabisulfite (K₂S₂O₅): Often demand high temperatures and phase transfer catalysts. Sodium hydroxymethylsulfonate (HOCH₂SO₂Na·2H₂O): Highly hygroscopic, leading...

γ-Ketosulfones are crucial building blocks in medicinal chemistry, serving as key bioactive components in antibacterial, anticoagulant, and antitumor drugs. However, traditional synthesis methods typically involve: Oxidation of γ-ketothioethers: Requires strong oxidants and harsh conditions. Derivatization of sulfinates: Involves cumbersome, multi-step processes. These limitations hinder broader applications, making it difficult to...

Sulfones are widely found in biomolecules and pharmaceuticals, serving as essential building blocks in synthetic chemistry. Similarly, the trifluoromethylthio (-SCF₃) group plays a crucial role in drug design and synthesis due to its strong electron-withdrawing properties. Professor Lian Zhong from Sichuan University has developed a Cu-catalyzed multicomponent reaction that enables...

Organometallic chemistry is a dynamic field that explores the synthesis, structure, reactivity, properties, and applications of metal-organic compounds. These compounds, formed by a central metal atom bonded to surrounding organic ligands, play a vital role in advancing modern science and technology. Among the most innovative developments in this field are Carbolong Complexes—a...

Carbolong Complexes are compounds formed by a planar conjugated carbon chain (carbon number ≥ 7) chelating a transition metal through at least 3 carbon-metal bonds. In 2013, Professor Xia Haiping's research group synthesized and named this type of compound for the first time [1]. This work was selected as one...