Fluorine is a vital non-metal element widely used in pharmaceuticals and agrochemicals. Due to its unique electronegativity, electronic effects, and steric hindrance, fluorine atoms are often introduced into drug molecules to enhance metabolic stability, permeability, and bioavailability. Over 20% of commercially available drugs and pesticides contain one or more fluorine...

Achieving selective catalytic oxidation by mimicking enzyme-like active sites remains a major scientific challenge. Professor Fang Yu’s group at Hunan University has developed a novel supramolecular photocatalyst PCC-6-M, based on phenothiazine ligands and octahedral porous coordination cages (PCCs). This innovative material enables precise regulation of reactive oxygen species (ROS) generation...

Metal–organic frameworks (MOFs) are crystalline porous materials formed by the self-assembly of metal ions or clusters and organic ligands. With their tunable structure, high porosity, and large surface area, nano-MOFs are widely applied in gas storage, molecular separation, and heterogeneous catalysis. J&K Scientific, in collaboration with Professor Yu Fang’s group...

The research group led by Professor Fang Yu at Hunan University has successfully developed a novel catalyst, PCC@THF-OOH, which achieves light-dark catalytic coupling. This breakthrough is based on a phenothiazine-based octahedral porous coordination cage (PCC-6-Zn), where the zinc metal center selectively generates singlet oxygen for oxidation reactions under light conditions...

Trifluoromethyldiazomethane (CF₃CHN₂), difluoromethyldiazomethane (CHF₂CHN₂), and formyldiazomethane (CHOCHN₂) are widely used as highly reactive reagents for trifluoromethylation, difluoromethylation, and formylation in the synthesis of organic fluorine compounds and aldehydes. However, these gases are toxic, volatile, and explosive, posing significant safety risks during production, storage, and use. Managing these safety concerns has...

Formyldiazomethane (CHOCHN₂) and difluoromethyldiazomethane (CHF₂CHN₂) are highly reactive, low-molecular-weight compounds widely used to introduce difluoromethyl or aldehyde groups into organic molecules. Despite their value, these functionalized diazomethane derivatives pose significant safety risks due to their gaseous state, volatility, toxicity, and explosiveness under standard conditions. Existing production methods require handling explosive...