Palladium(II) Acetate (CAS No. 3375-31-3) is one of the most widely used palladium catalysts and Pd(II) catalyst precursors in modern organic synthesis. Owing to its excellent solubility in a variety of organic solvents and high catalytic activity, it is extensively employed in cross-coupling reactions, C–H activation, carbonylation, oxidation, hydrogenation, and organometallic chemistry. Palladium(II) acetate serves as a versatile precursor for numerous phosphine- and NHC-ligated palladium catalysts and is indispensable in pharmaceutical, agrochemical, fine chemical, and materials research.
| Property | Value |
|---|---|
| Chemical Name | Palladium(II) Acetate |
| Synonyms | Palladium Diacetate; Acetic Acid Palladium(II) Salt |
| CAS Number | 3375-31-3 |
| Molecular Formula | C₄H₆O₄Pd |
| Molecular Weight | 224.51 g/mol |
| Appearance | Brown to reddish-brown crystalline powder |
| Purity | Typically ≥98% |
| Storage | Store at room temperature under dry conditions |
Palladium(II) acetate is among the most frequently used palladium sources for carbon–carbon and carbon–heteroatom bond formation.
Typical applications include:
Pd(OAc)₂ is widely employed in direct C–H functionalization reactions, enabling efficient synthesis without prefunctionalized substrates.
Typical applications include:
The catalyst plays a critical role in the synthesis of complex pharmaceutical intermediates and high-value specialty chemicals.
Typical applications include:
Palladium(II) acetate serves as a versatile precursor for preparing homogeneous palladium catalysts and coordination complexes.
Typical applications include:
Pd(OAc)₂ is widely used in the preparation of functional materials and nanostructured palladium catalysts.
Typical applications include:
| Parameter | Recommended Conditions |
|---|---|
| Storage Temperature | Room temperature |
| Atmosphere | Dry atmosphere recommended |
| Moisture Protection | Recommended |
| Light Protection | Store away from prolonged light exposure |
| Common Solvents | Acetonitrile, DMF, DMSO, THF, acetone, acetic acid |
Palladium(II) acetate is primarily used as a Pd(II) catalyst precursor for cross-coupling reactions, C–H activation, oxidation, and numerous catalytic transformations in organic synthesis.
It is widely employed in Suzuki–Miyaura, Heck, Sonogashira, Stille, Negishi, and Buchwald–Hartwig coupling reactions.
It is easily reduced to catalytically active Pd(0), dissolves readily in many organic solvents, and is compatible with numerous phosphine and NHC ligands, making it one of the most versatile palladium sources.
Yes. Pd(OAc)₂ is one of the most commonly used catalysts for direct C–H functionalization, including arylation, alkylation, acetoxylation, and olefination.
Yes. It is extensively used in API synthesis, medicinal chemistry, process development, and industrial-scale catalytic manufacturing.
Store in a tightly sealed container at room temperature under dry conditions. Protect the material from moisture and incompatible reducing agents.
Yes. This product is supplied for laboratory research, catalyst development, analytical applications, and industrial R&D use only.
